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Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study

Hanly, J. G.; Urowitz, M. B.; Su, L.; Sanchez-Guerrero, J.; Bae, S. C.; Gordon, C.; Wallace, D. J.; Isenberg, D.; Alarcon, G. S. and Merrill, J. T., et al. (2008) In Arthritis and Rheumatism 59(5). p.721-729
Abstract
Objective. To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). Methods. The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. Results. There were 890 patients (88.7% female) with a mean +/- SD age of 33.8... (More)
Objective. To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). Methods. The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. Results. There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events. Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
59
issue
5
pages
721 - 729
publisher
John Wiley & Sons
external identifiers
  • wos:000255848000017
  • scopus:43549088352
ISSN
1529-0131
DOI
10.1002/art.23566
language
English
LU publication?
yes
id
d91292b1-88a3-4b44-9c68-8c7a4a34e70d (old id 1204392)
date added to LUP
2008-09-17 13:08:43
date last changed
2017-11-05 03:45:58
@article{d91292b1-88a3-4b44-9c68-8c7a4a34e70d,
  abstract     = {Objective. To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). Methods. The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. Results. There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events. Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.},
  author       = {Hanly, J. G. and Urowitz, M. B. and Su, L. and Sanchez-Guerrero, J. and Bae, S. C. and Gordon, C. and Wallace, D. J. and Isenberg, D. and Alarcon, G. S. and Merrill, J. T. and Clarke, A. and Bernatsky, S. and Dooley, M. A. and Fortin, P. R. and Gladman, D. and Steinsson, K. and Petri, M. and Bruce, I. N. and Manzi, S. and Khamashta, M. and Zoma, A. and Font, J. and Van Vollenhoven, R. and Aranow, C. and Ginzler, E. and Nived, Ola and Sturfelt, Gunnar and Ramsey-Goldman, R. and Kalunian, K. and Douglas, J. and Qi, K. Qiufen and Thompson, K. and Farewell, V.},
  issn         = {1529-0131},
  language     = {eng},
  number       = {5},
  pages        = {721--729},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study},
  url          = {http://dx.doi.org/10.1002/art.23566},
  volume       = {59},
  year         = {2008},
}