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Role of ABO secretor status in mucosal innate immunity and H. pylori infection

Linden, Sara; Mahdavi, Jafar; Semino-Mora, Cristina; Olsen, Cara; Carlstedt, Ingemar LU ; Boren, Thomas and Dubois, Andre (2008) In PLoS Pathogens 4(1). p.0006-0013
Abstract
The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of the ABO blood group system is unknown. Gastric mucosa biopsies of 41 Rhesus monkeys originating from Southern Asia were analyzed by immunohistochemistry. A majority of these animals were found to be of blood group B and weak-secretor phenotype (i.e., expressing both Lewis a and Lewis b antigens), which are also common in South Asian human populations. A selected group of ten monkeys was inoculated with Helicobacter pylori and studied for changes in gastric mucosal glycosylation during a... (More)
The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of the ABO blood group system is unknown. Gastric mucosa biopsies of 41 Rhesus monkeys originating from Southern Asia were analyzed by immunohistochemistry. A majority of these animals were found to be of blood group B and weak-secretor phenotype (i.e., expressing both Lewis a and Lewis b antigens), which are also common in South Asian human populations. A selected group of ten monkeys was inoculated with Helicobacter pylori and studied for changes in gastric mucosal glycosylation during a 10-month period. We observed a loss in mucosal fucosylation and concurrent induction and time-dependent dynamics in gastric mucosal sialylation (carbohydrate marker of inflammation), which affect H. pylori adhesion targets and thus modulate host-bacterial interactions. Of particular relevance, gastric mucosal density of H. pylori, gastritis, and sialylation were all higher in secretor individuals compared to weak-secretors, the latter being apparently "protected.'' These results demonstrate that the secretor status plays an intrinsic role in resistance to H. pylori infection and suggest that the fucosylated secretor ABH antigens constitute interactive members of the human and primate mucosal innate immune system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Pathogens
volume
4
issue
1
pages
0006 - 0013
publisher
Public Library of Science
external identifiers
  • wos:000255412300013
ISSN
1553-7366
DOI
10.1371/journal.ppat.0040002
language
English
LU publication?
yes
id
90ad18a8-a027-4eaa-9a3c-ffaaec6c1e38 (old id 1204552)
date added to LUP
2008-09-17 14:19:33
date last changed
2016-04-15 20:42:16
@article{90ad18a8-a027-4eaa-9a3c-ffaaec6c1e38,
  abstract     = {The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of the ABO blood group system is unknown. Gastric mucosa biopsies of 41 Rhesus monkeys originating from Southern Asia were analyzed by immunohistochemistry. A majority of these animals were found to be of blood group B and weak-secretor phenotype (i.e., expressing both Lewis a and Lewis b antigens), which are also common in South Asian human populations. A selected group of ten monkeys was inoculated with Helicobacter pylori and studied for changes in gastric mucosal glycosylation during a 10-month period. We observed a loss in mucosal fucosylation and concurrent induction and time-dependent dynamics in gastric mucosal sialylation (carbohydrate marker of inflammation), which affect H. pylori adhesion targets and thus modulate host-bacterial interactions. Of particular relevance, gastric mucosal density of H. pylori, gastritis, and sialylation were all higher in secretor individuals compared to weak-secretors, the latter being apparently "protected.'' These results demonstrate that the secretor status plays an intrinsic role in resistance to H. pylori infection and suggest that the fucosylated secretor ABH antigens constitute interactive members of the human and primate mucosal innate immune system.},
  author       = {Linden, Sara and Mahdavi, Jafar and Semino-Mora, Cristina and Olsen, Cara and Carlstedt, Ingemar and Boren, Thomas and Dubois, Andre},
  issn         = {1553-7366},
  language     = {eng},
  number       = {1},
  pages        = {0006--0013},
  publisher    = {Public Library of Science},
  series       = {PLoS Pathogens},
  title        = {Role of ABO secretor status in mucosal innate immunity and H. pylori infection},
  url          = {http://dx.doi.org/10.1371/journal.ppat.0040002},
  volume       = {4},
  year         = {2008},
}