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Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets

Rolf, Julia LU ; Berntman, Emma LU ; Stenström, Martin LU ; Smith, Emma LU ; Månsson, Robert LU ; Stenstad, Hanna LU ; Yamagata, Tetsuya; Agace, William LU ; Sigvardsson, Mikael LU and Cardell, Susanna LU (2008) In Molecular Immunology 45(9). p.2607-2620
Abstract
CD1d-restricted natural killer T (NKT) cells can have multiple effects on an immune response, including the activation, regulation and attraction of innate immune cells, and modulation of adaptive immunity. Recent studies reveal that there are distinct subsets of NKT cells which selectively perform some of the functions attributed to CD1d-restricted cells, but the mechanisms underlying these functional differences have not been resolved. Our aim in this study was to identify novel NKT cell associated traits that would provide important insight into NKT cell activation and function. To this end, we have performed gene expression profiling of two separate subsets of NKT cells, analyzing genes differentially expressed in these cells compared... (More)
CD1d-restricted natural killer T (NKT) cells can have multiple effects on an immune response, including the activation, regulation and attraction of innate immune cells, and modulation of adaptive immunity. Recent studies reveal that there are distinct subsets of NKT cells which selectively perform some of the functions attributed to CD1d-restricted cells, but the mechanisms underlying these functional differences have not been resolved. Our aim in this study was to identify novel NKT cell associated traits that would provide important insight into NKT cell activation and function. To this end, we have performed gene expression profiling of two separate subsets of NKT cells, analyzing genes differentially expressed in these cells compared to conventional CD4(+)NK1.1(-) T cells. We identify different sets of genes over expressed in each of the two NKT cell types, as well as genes that are common to the two CD1d-restricted NKT cell populations analyzed. A large number of these genes are highly relevant for NKT cell development, activation and function. Each NKT subtype displayed a unique set of chemokine receptors, integrins and molecules related to effector function, supporting the notion that distinct NKT cells can be selectively engaged and have diverse functions in different types of immune reactions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene expression, NKT cells, CD1d, transcription factors
in
Molecular Immunology
volume
45
issue
9
pages
2607 - 2620
publisher
Pergamon
external identifiers
  • wos:000255528400018
  • scopus:40849101435
ISSN
1872-9142
DOI
10.1016/j.molimm.2007.12.022
language
English
LU publication?
yes
id
82944c1e-e93d-4689-ab40-63f937ee3bbc (old id 1205241)
date added to LUP
2008-09-18 13:53:27
date last changed
2017-03-26 04:03:08
@article{82944c1e-e93d-4689-ab40-63f937ee3bbc,
  abstract     = {CD1d-restricted natural killer T (NKT) cells can have multiple effects on an immune response, including the activation, regulation and attraction of innate immune cells, and modulation of adaptive immunity. Recent studies reveal that there are distinct subsets of NKT cells which selectively perform some of the functions attributed to CD1d-restricted cells, but the mechanisms underlying these functional differences have not been resolved. Our aim in this study was to identify novel NKT cell associated traits that would provide important insight into NKT cell activation and function. To this end, we have performed gene expression profiling of two separate subsets of NKT cells, analyzing genes differentially expressed in these cells compared to conventional CD4(+)NK1.1(-) T cells. We identify different sets of genes over expressed in each of the two NKT cell types, as well as genes that are common to the two CD1d-restricted NKT cell populations analyzed. A large number of these genes are highly relevant for NKT cell development, activation and function. Each NKT subtype displayed a unique set of chemokine receptors, integrins and molecules related to effector function, supporting the notion that distinct NKT cells can be selectively engaged and have diverse functions in different types of immune reactions.},
  author       = {Rolf, Julia and Berntman, Emma and Stenström, Martin and Smith, Emma and Månsson, Robert and Stenstad, Hanna and Yamagata, Tetsuya and Agace, William and Sigvardsson, Mikael and Cardell, Susanna},
  issn         = {1872-9142},
  keyword      = {gene expression,NKT cells,CD1d,transcription factors},
  language     = {eng},
  number       = {9},
  pages        = {2607--2620},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets},
  url          = {http://dx.doi.org/10.1016/j.molimm.2007.12.022},
  volume       = {45},
  year         = {2008},
}