Advanced

Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study

Prompers, L.; Schaper, N.; Apelqvist, Jan LU ; Edmonds, M.; Jude, E.; Mauricio, D.; Uccioli, L.; Urbancic, V.; Bakker, K. and Holstein, P., et al. (2008) In Diabetologia 51(5). p.747-755
Abstract
Aims/hypothesis Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome in a large population of diabetic foot ulcer patients and examined whether such predictors differ between patients with and without PAD. Methods Analyses were conducted within the EURODIALE Study, a prospective cohort study of 1,088 diabetic foot ulcer patients across 14 centres in Europe. Multiple logistic regression modelling was used to identify independent predictors of outcome (i.e. non-healing of the foot ulcer). Results After 1 year of follow-up, 23% of the patients had not healed. Independent baseline predictors... (More)
Aims/hypothesis Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome in a large population of diabetic foot ulcer patients and examined whether such predictors differ between patients with and without PAD. Methods Analyses were conducted within the EURODIALE Study, a prospective cohort study of 1,088 diabetic foot ulcer patients across 14 centres in Europe. Multiple logistic regression modelling was used to identify independent predictors of outcome (i.e. non-healing of the foot ulcer). Results After 1 year of follow-up, 23% of the patients had not healed. Independent baseline predictors of non-healing in the whole study population were older age, male sex, heart failure, the inability to stand or walk without help, end-stage renal disease, larger ulcer size, peripheral neuropathy and PAD. When analyses were performed according to PAD status, infection emerged as a specific predictor of non-healing in PAD patients only. Conclusions/Interpretation Predictors of healing differ between patients with and without PAD, suggesting that diabetic foot ulcers with or without concomitant PAD should be defined as two separate disease states. The observed negative impact of infection on healing that was confined to patients with PAD needs further investigation. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
predictive model, peripheral arterial disease, outcome, non-healing, infection, foot ulcer, co-morbidities, diabetes
in
Diabetologia
volume
51
issue
5
pages
747 - 755
publisher
Springer Verlag
external identifiers
  • wos:000254750400007
  • scopus:41849139963
ISSN
1432-0428
DOI
10.1007/s00125-008-0940-0
language
English
LU publication?
yes
id
2e91e10f-c4b2-4e6e-a29e-df3d834e231a (old id 1207267)
date added to LUP
2008-08-28 13:57:19
date last changed
2017-11-05 03:29:30
@article{2e91e10f-c4b2-4e6e-a29e-df3d834e231a,
  abstract     = {Aims/hypothesis Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome in a large population of diabetic foot ulcer patients and examined whether such predictors differ between patients with and without PAD. Methods Analyses were conducted within the EURODIALE Study, a prospective cohort study of 1,088 diabetic foot ulcer patients across 14 centres in Europe. Multiple logistic regression modelling was used to identify independent predictors of outcome (i.e. non-healing of the foot ulcer). Results After 1 year of follow-up, 23% of the patients had not healed. Independent baseline predictors of non-healing in the whole study population were older age, male sex, heart failure, the inability to stand or walk without help, end-stage renal disease, larger ulcer size, peripheral neuropathy and PAD. When analyses were performed according to PAD status, infection emerged as a specific predictor of non-healing in PAD patients only. Conclusions/Interpretation Predictors of healing differ between patients with and without PAD, suggesting that diabetic foot ulcers with or without concomitant PAD should be defined as two separate disease states. The observed negative impact of infection on healing that was confined to patients with PAD needs further investigation.},
  author       = {Prompers, L. and Schaper, N. and Apelqvist, Jan and Edmonds, M. and Jude, E. and Mauricio, D. and Uccioli, L. and Urbancic, V. and Bakker, K. and Holstein, P. and Jirkovska, A. and Piaggesi, A. and Ragnarson-Tennvall, G and Reike, H. and Spraul, M. and Van Acker, K. and Van Baal, J. and Van Merode, F. and Ferreira, I. and Huijberts, M.},
  issn         = {1432-0428},
  keyword      = {predictive model,peripheral arterial disease,outcome,non-healing,infection,foot ulcer,co-morbidities,diabetes},
  language     = {eng},
  number       = {5},
  pages        = {747--755},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study},
  url          = {http://dx.doi.org/10.1007/s00125-008-0940-0},
  volume       = {51},
  year         = {2008},
}