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Family burden of cardiovascular mortality: risk implications for offspring in a national register linkage study based upon the Malmö Preventive Project.

Nilsson, P M; Nilsson, Jan-Åke LU and Berglund, Göran LU (2004) In Journal of Internal Medicine1989-01-01+01:00 255(2). p.229-235
Abstract
Objective. To investigate the adjusted relative risk of cardiovascular disease (CVD) events in offspring of parents with cardiovascular mortality before 75 years.



Setting. The city of Malmö, Sweden.



Design. A follow-up study based on register linkage analyses.



Subjects and methods. In the Malmö Preventive Project (MPP), a total of 22 444 men and 10 902 women attended the screening programme between 1974 and 1992. At the screening conventional risk factors for CVD were measured (blood pressure, lipids, glucose, smoking and social class).



Main outcome measures. Parental CVD mortality was determined via register linkage analysis between the Multiple-Generation... (More)
Objective. To investigate the adjusted relative risk of cardiovascular disease (CVD) events in offspring of parents with cardiovascular mortality before 75 years.



Setting. The city of Malmö, Sweden.



Design. A follow-up study based on register linkage analyses.



Subjects and methods. In the Malmö Preventive Project (MPP), a total of 22 444 men and 10 902 women attended the screening programme between 1974 and 1992. At the screening conventional risk factors for CVD were measured (blood pressure, lipids, glucose, smoking and social class).



Main outcome measures. Parental CVD mortality was determined via register linkage analysis between the Multiple-Generation Register and the National Mortality Register (NMR). CVD events (morbidity and mortality) in offspring were collected from national registers. The relative risk for CVD events in offspring, in relation to parental CVD mortality, was adjusted for age and risk factors at screening.



Results. The age-adjusted relative risk (RR; 95%CI) for a son to experience a CVD event was increased in relation to a maternal positive family history of CVD mortality before 75 years when compared with no maternal history, RR 1.74 (1.43-2.11). This RR decreased to 1.51 (1.23-1.84; P < 0.001) after full adjustment for risk factors. The corresponding fully adjusted RRs for father-son heritage was RR 1.22 (1.02-1.47; P < 0.05), mother-daughter RR 0.87 (0.54-1.41), and father-daughter RR 1.20 (0.83-1.73).



Conclusion. The existence of maternal CVD mortality before the age of 75 years implies a substantial risk increase for CVD morbidity and mortality in sons that cannot be explained by social background, lifestyle, or conventional cardiovascular risk factors in the adult offspring. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine1989-01-01+01:00
volume
255
issue
2
pages
229 - 235
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000188411100008
  • pmid:14746560
  • scopus:1242317782
ISSN
1365-2796
DOI
10.1046/j.1365-2796.2003.01287.x
language
English
LU publication?
yes
id
904f17bd-eb29-4a6b-a8dc-7e18d730bd7b (old id 120840)
date added to LUP
2007-07-26 15:58:56
date last changed
2017-10-22 04:46:08
@article{904f17bd-eb29-4a6b-a8dc-7e18d730bd7b,
  abstract     = {Objective. To investigate the adjusted relative risk of cardiovascular disease (CVD) events in offspring of parents with cardiovascular mortality before 75 years.<br/><br>
<br/><br>
Setting. The city of Malmö, Sweden.<br/><br>
<br/><br>
Design. A follow-up study based on register linkage analyses.<br/><br>
<br/><br>
Subjects and methods. In the Malmö Preventive Project (MPP), a total of 22 444 men and 10 902 women attended the screening programme between 1974 and 1992. At the screening conventional risk factors for CVD were measured (blood pressure, lipids, glucose, smoking and social class).<br/><br>
<br/><br>
Main outcome measures. Parental CVD mortality was determined via register linkage analysis between the Multiple-Generation Register and the National Mortality Register (NMR). CVD events (morbidity and mortality) in offspring were collected from national registers. The relative risk for CVD events in offspring, in relation to parental CVD mortality, was adjusted for age and risk factors at screening.<br/><br>
<br/><br>
Results. The age-adjusted relative risk (RR; 95%CI) for a son to experience a CVD event was increased in relation to a maternal positive family history of CVD mortality before 75 years when compared with no maternal history, RR 1.74 (1.43-2.11). This RR decreased to 1.51 (1.23-1.84; P &lt; 0.001) after full adjustment for risk factors. The corresponding fully adjusted RRs for father-son heritage was RR 1.22 (1.02-1.47; P &lt; 0.05), mother-daughter RR 0.87 (0.54-1.41), and father-daughter RR 1.20 (0.83-1.73).<br/><br>
<br/><br>
Conclusion. The existence of maternal CVD mortality before the age of 75 years implies a substantial risk increase for CVD morbidity and mortality in sons that cannot be explained by social background, lifestyle, or conventional cardiovascular risk factors in the adult offspring.},
  author       = {Nilsson, P M and Nilsson, Jan-Åke and Berglund, Göran},
  issn         = {1365-2796},
  language     = {eng},
  number       = {2},
  pages        = {229--235},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {Family burden of cardiovascular mortality: risk implications for offspring in a national register linkage study based upon the Malmö Preventive Project.},
  url          = {http://dx.doi.org/10.1046/j.1365-2796.2003.01287.x},
  volume       = {255},
  year         = {2004},
}