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Reduced functional performance in the lower extremity predicted radiographic knee osteoarthritis five years later.

Thorstensson, C A; Petersson, I F; Jacobsson, L T H; Boegård, T L and Roos, Ewa LU (2004) In Annals of the Rheumatic Diseases 63(4). p.402-407
Abstract
Background: Reduced quadriceps strength is an early finding in subjects with knee osteoarthritis, but it is not clear whether it is a cause or a consequence of knee osteoarthritis.



Objective: To determine whether reduced functional performance in the lower extremity predicts the incidence or progression of radiographic knee osteoarthritis.



Design: Prospective, epidemiological, population based cohort study.



Patients: 148 subjects (62 women), aged 35–54 (mean 44.8), with chronic knee pain from a population based cohort.



Measurements: Predictors analysed were age, sex, body mass index, baseline knee pain, and three tests of lower extremity functional performance:... (More)
Background: Reduced quadriceps strength is an early finding in subjects with knee osteoarthritis, but it is not clear whether it is a cause or a consequence of knee osteoarthritis.



Objective: To determine whether reduced functional performance in the lower extremity predicts the incidence or progression of radiographic knee osteoarthritis.



Design: Prospective, epidemiological, population based cohort study.



Patients: 148 subjects (62 women), aged 35–54 (mean 44.8), with chronic knee pain from a population based cohort.



Measurements: Predictors analysed were age, sex, body mass index, baseline knee pain, and three tests of lower extremity functional performance: maximum number of one-leg rises from sitting, time spent walking 300 m, and timed standing on one leg. Weightbearing tibiofemoral knee radiographs were obtained at baseline and after 5 years (median 5.1, range 4.2–6.1), and classified according to Kellgren and Lawrence as no osteoarthritis (Kellgren and Lawrence = 0, n = 94) or prevalent osteoarthritis (Kellgren and Lawrence >=1, n = 54).



Results: Fewer one-leg rises (median 17 v 25) predicted incident radiographic osteoarthritis five years later (OR 2.6, 95% CI 1.1 to 6.0). The association remained significant after controlling for age, sex, body mass index, and pain. No significant predictor of radiographic progression in the group with prevalent osteoarthritis was found.



Conclusion: Reduced functional performance in the lower extremity predicted development of radiographic knee osteoarthritis 5 years later among people aged 35–55 with chronic knee pain and normal radiographs at baseline. These findings suggest that a test of one-leg rises may be useful, and interventions aimed at improving functional performance may be protective against development of knee osteoarthritis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
63
issue
4
pages
402 - 407
publisher
British Medical Association
external identifiers
  • pmid:15020334
  • wos:000220198000014
  • scopus:1842505674
ISSN
1468-2060
DOI
10.1136/ard.2003.007583
language
English
LU publication?
yes
id
00021499-ed23-418c-9537-b3ba4a3f2fde (old id 121267)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15020334&dopt=Abstract
date added to LUP
2007-07-04 09:59:19
date last changed
2017-11-12 03:54:37
@article{00021499-ed23-418c-9537-b3ba4a3f2fde,
  abstract     = {Background: Reduced quadriceps strength is an early finding in subjects with knee osteoarthritis, but it is not clear whether it is a cause or a consequence of knee osteoarthritis.<br/><br>
<br/><br>
Objective: To determine whether reduced functional performance in the lower extremity predicts the incidence or progression of radiographic knee osteoarthritis.<br/><br>
<br/><br>
Design: Prospective, epidemiological, population based cohort study.<br/><br>
<br/><br>
Patients: 148 subjects (62 women), aged 35–54 (mean 44.8), with chronic knee pain from a population based cohort.<br/><br>
<br/><br>
Measurements: Predictors analysed were age, sex, body mass index, baseline knee pain, and three tests of lower extremity functional performance: maximum number of one-leg rises from sitting, time spent walking 300 m, and timed standing on one leg. Weightbearing tibiofemoral knee radiographs were obtained at baseline and after 5 years (median 5.1, range 4.2–6.1), and classified according to Kellgren and Lawrence as no osteoarthritis (Kellgren and Lawrence = 0, n = 94) or prevalent osteoarthritis (Kellgren and Lawrence &gt;=1, n = 54).<br/><br>
<br/><br>
Results: Fewer one-leg rises (median 17 v 25) predicted incident radiographic osteoarthritis five years later (OR 2.6, 95% CI 1.1 to 6.0). The association remained significant after controlling for age, sex, body mass index, and pain. No significant predictor of radiographic progression in the group with prevalent osteoarthritis was found.<br/><br>
<br/><br>
Conclusion: Reduced functional performance in the lower extremity predicted development of radiographic knee osteoarthritis 5 years later among people aged 35–55 with chronic knee pain and normal radiographs at baseline. These findings suggest that a test of one-leg rises may be useful, and interventions aimed at improving functional performance may be protective against development of knee osteoarthritis.},
  author       = {Thorstensson, C A and Petersson, I F and Jacobsson, L T H and Boegård, T L and Roos, Ewa},
  issn         = {1468-2060},
  language     = {eng},
  number       = {4},
  pages        = {402--407},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Reduced functional performance in the lower extremity predicted radiographic knee osteoarthritis five years later.},
  url          = {http://dx.doi.org/10.1136/ard.2003.007583},
  volume       = {63},
  year         = {2004},
}