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High Brain Tissue Oxygen Tension during Ventilation with 100% Oxygen after Fetal Asphyxia in Newborn Sheep.

Perez de Sá, Valéria LU ; Cunha Goncalves, Doris LU ; Nord, Anders LU ; Hansson, Stefan LU ; Larsson, Anders; Ley, David LU ; Fellman, Vineta LU and Werner, Olof LU (2009) In Pediatric Research Aug 13. p.57-61
Abstract
The optimal FiO2 for newborn resuscitation is still not settled. We hypothesized that short-lasting oxygen ventilation after intrauterine asphyxia would not cause arterial or cerebral hyperoxia, and therefore be innocuous. The umbilical cord of fetal sheep was clamped and 10 min later, after delivery, ventilation with air (n=7) or with 100% oxygen for 3 (n=6) or 30 min (n=5), followed by air, was started. Among the eleven lambs given 100% O2, oxygen tension (PO2) was 10.7 (1.8 - 56) kPa [median (range)] in arterial samples taken after 2.5 min of ventilation. In those ventilated with 100% oxygen for 30 min, brain tissue PO2 (PbtO2) increased from less than 0.1 kPa in each lamb to individual maxima of 56 (30-61) kPa, while in those given... (More)
The optimal FiO2 for newborn resuscitation is still not settled. We hypothesized that short-lasting oxygen ventilation after intrauterine asphyxia would not cause arterial or cerebral hyperoxia, and therefore be innocuous. The umbilical cord of fetal sheep was clamped and 10 min later, after delivery, ventilation with air (n=7) or with 100% oxygen for 3 (n=6) or 30 min (n=5), followed by air, was started. Among the eleven lambs given 100% O2, oxygen tension (PO2) was 10.7 (1.8 - 56) kPa [median (range)] in arterial samples taken after 2.5 min of ventilation. In those ventilated with 100% oxygen for 30 min, brain tissue PO2 (PbtO2) increased from less than 0.1 kPa in each lamb to individual maxima of 56 (30-61) kPa, while in those given oxygenfor just 3 min, PbtO2peaked at 4.2 (2.9 - 46) kPa. The maximal PbtO2 in air-ventilated lambs was 2.9 (0.8-5.4) kPa. Heart rate and blood pressure increased equally fast in the three groups. Thus, prolonged ventilation with 100% oxygen caused an increase in PbtO2of a magnitude previously only reported under hyperbaric conditions. Reducing the time of 100% oxygen ventilation to 3 min did not consistently avert systemic hyperoxia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
Aug 13
pages
57 - 61
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000261910700010
  • pmid:18703995
  • scopus:58149394846
ISSN
1530-0447
DOI
10.1203/PDR.0b013e31818a01a4
language
English
LU publication?
yes
id
65378652-04e7-470e-9978-15a2726ab1b4 (old id 1223213)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18703995?dopt=Abstract
date added to LUP
2008-09-02 14:52:09
date last changed
2017-12-10 04:41:08
@article{65378652-04e7-470e-9978-15a2726ab1b4,
  abstract     = {The optimal FiO2 for newborn resuscitation is still not settled. We hypothesized that short-lasting oxygen ventilation after intrauterine asphyxia would not cause arterial or cerebral hyperoxia, and therefore be innocuous. The umbilical cord of fetal sheep was clamped and 10 min later, after delivery, ventilation with air (n=7) or with 100% oxygen for 3 (n=6) or 30 min (n=5), followed by air, was started. Among the eleven lambs given 100% O2, oxygen tension (PO2) was 10.7 (1.8 - 56) kPa [median (range)] in arterial samples taken after 2.5 min of ventilation. In those ventilated with 100% oxygen for 30 min, brain tissue PO2 (PbtO2) increased from less than 0.1 kPa in each lamb to individual maxima of 56 (30-61) kPa, while in those given oxygenfor just 3 min, PbtO2peaked at 4.2 (2.9 - 46) kPa. The maximal PbtO2 in air-ventilated lambs was 2.9 (0.8-5.4) kPa. Heart rate and blood pressure increased equally fast in the three groups. Thus, prolonged ventilation with 100% oxygen caused an increase in PbtO2of a magnitude previously only reported under hyperbaric conditions. Reducing the time of 100% oxygen ventilation to 3 min did not consistently avert systemic hyperoxia.},
  author       = {Perez de Sá, Valéria and Cunha Goncalves, Doris and Nord, Anders and Hansson, Stefan and Larsson, Anders and Ley, David and Fellman, Vineta and Werner, Olof},
  issn         = {1530-0447},
  language     = {eng},
  pages        = {57--61},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {High Brain Tissue Oxygen Tension during Ventilation with 100% Oxygen after Fetal Asphyxia in Newborn Sheep.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e31818a01a4},
  volume       = {Aug 13},
  year         = {2009},
}