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Prevalence of dementia subtypes: A 30-year retrospective survey of neuropathological reports.

Brunnström, Hans LU orcid ; Gustafson, Lars LU ; Passant, Ulla LU and Englund, Elisabet LU orcid (2009) In Archives of Gerontology and Geriatrics Aug 7. p.146-149
Abstract
We investigated the distribution of neuropathologically defined dementia subtypes among individuals with dementia disorder. The neuropathological reports were studied on all patients (n=524; 55.3% females; median age 80, range 39-102 years) with clinically diagnosed dementia disorder who underwent complete autopsy including neuropathological examination within the Department of Pathology at the University Hospital in Lund, Sweden, during the years 1974-2004. The neuropathological diagnosis was Alzheimer's disease (AD) in 42.0% of the cases, vascular dementia (VaD) in 23.7%, dementia of combined Alzheimer and vascular pathology in 21.6%, and frontotemporal dementia in 4.0% of the patients. The remaining 8.8% of the patients had other... (More)
We investigated the distribution of neuropathologically defined dementia subtypes among individuals with dementia disorder. The neuropathological reports were studied on all patients (n=524; 55.3% females; median age 80, range 39-102 years) with clinically diagnosed dementia disorder who underwent complete autopsy including neuropathological examination within the Department of Pathology at the University Hospital in Lund, Sweden, during the years 1974-2004. The neuropathological diagnosis was Alzheimer's disease (AD) in 42.0% of the cases, vascular dementia (VaD) in 23.7%, dementia of combined Alzheimer and vascular pathology in 21.6%, and frontotemporal dementia in 4.0% of the patients. The remaining 8.8% of the patients had other dementia disorders, including combinations other than combined Alzheimer and vascular pathology. The registered prevalence of dementia subtypes depends on many variables, including referral habits, clinical and neuropathological judgments and diagnostic traditions, all of these variables potentially changing over time. This, however, does not seem to obscure the delineation of the major dementia subgroups. In this material of 30 years from Lund in the south of Sweden, AD by far dominated among dementia subtypes, while cerebrovascular pathology corresponded with the dementia disorder, either entirely or partly, in almost half of the demented patients. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Gerontology and Geriatrics
volume
Aug 7
pages
146 - 149
publisher
Elsevier
external identifiers
  • wos:000266733300029
  • pmid:18692255
  • scopus:67349283552
  • pmid:18692255
ISSN
1872-6976
DOI
10.1016/j.archger.2008.06.005
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)
id
c5fb142d-7ed0-444b-9123-83959167b508 (old id 1223338)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18692255?dopt=Abstract
date added to LUP
2016-04-04 09:42:17
date last changed
2021-08-11 04:35:21
@article{c5fb142d-7ed0-444b-9123-83959167b508,
  abstract     = {We investigated the distribution of neuropathologically defined dementia subtypes among individuals with dementia disorder. The neuropathological reports were studied on all patients (n=524; 55.3% females; median age 80, range 39-102 years) with clinically diagnosed dementia disorder who underwent complete autopsy including neuropathological examination within the Department of Pathology at the University Hospital in Lund, Sweden, during the years 1974-2004. The neuropathological diagnosis was Alzheimer's disease (AD) in 42.0% of the cases, vascular dementia (VaD) in 23.7%, dementia of combined Alzheimer and vascular pathology in 21.6%, and frontotemporal dementia in 4.0% of the patients. The remaining 8.8% of the patients had other dementia disorders, including combinations other than combined Alzheimer and vascular pathology. The registered prevalence of dementia subtypes depends on many variables, including referral habits, clinical and neuropathological judgments and diagnostic traditions, all of these variables potentially changing over time. This, however, does not seem to obscure the delineation of the major dementia subgroups. In this material of 30 years from Lund in the south of Sweden, AD by far dominated among dementia subtypes, while cerebrovascular pathology corresponded with the dementia disorder, either entirely or partly, in almost half of the demented patients.},
  author       = {Brunnström, Hans and Gustafson, Lars and Passant, Ulla and Englund, Elisabet},
  issn         = {1872-6976},
  language     = {eng},
  pages        = {146--149},
  publisher    = {Elsevier},
  series       = {Archives of Gerontology and Geriatrics},
  title        = {Prevalence of dementia subtypes: A 30-year retrospective survey of neuropathological reports.},
  url          = {https://lup.lub.lu.se/search/files/5395151/1296042.pdf},
  doi          = {10.1016/j.archger.2008.06.005},
  volume       = {Aug 7},
  year         = {2009},
}