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Differences in transcriptional activity of cutaneous human papillomaviruses.

Vasiljevic, Natasa LU ; Nielsen, Lone; Doherty, Geoff; Dillner, Joakim LU ; Forslund, Ola LU and Norrild, Bodil (2008) In Virus Research Aug 6. p.213-219
Abstract
The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation... (More)
The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation activated HPV-8 but inhibited HPV-38 and HPV-93 whereas HPV-92 and 96 were not affected. As there are variable UV-B responses among the HPV types, further studies of interactions between UV-B and HPV need to consider the HPV type. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Virus Research
volume
Aug 6
pages
213 - 219
publisher
Elsevier
external identifiers
  • wos:000261047600006
  • pmid:18692100
  • scopus:53749083668
ISSN
1872-7492
DOI
10.1016/j.virusres.2008.07.013
language
English
LU publication?
yes
id
fb98fb40-ea01-4575-81cd-39c55edc7f19 (old id 1223361)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18692100?dopt=Abstract
date added to LUP
2008-09-02 13:21:18
date last changed
2017-01-01 07:39:48
@article{fb98fb40-ea01-4575-81cd-39c55edc7f19,
  abstract     = {The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation activated HPV-8 but inhibited HPV-38 and HPV-93 whereas HPV-92 and 96 were not affected. As there are variable UV-B responses among the HPV types, further studies of interactions between UV-B and HPV need to consider the HPV type.},
  author       = {Vasiljevic, Natasa and Nielsen, Lone and Doherty, Geoff and Dillner, Joakim and Forslund, Ola and Norrild, Bodil},
  issn         = {1872-7492},
  language     = {eng},
  pages        = {213--219},
  publisher    = {Elsevier},
  series       = {Virus Research},
  title        = {Differences in transcriptional activity of cutaneous human papillomaviruses.},
  url          = {http://dx.doi.org/10.1016/j.virusres.2008.07.013},
  volume       = {Aug 6},
  year         = {2008},
}