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Differences in transcriptional activity of cutaneous human papillomaviruses.

Vasiljevic, Natasa LU ; Nielsen, Lone ; Doherty, Geoff ; Dillner, Joakim LU ; Forslund, Ola LU and Norrild, Bodil (2008) In Virus Research Aug 6. p.213-219
Abstract
The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation... (More)
The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation activated HPV-8 but inhibited HPV-38 and HPV-93 whereas HPV-92 and 96 were not affected. As there are variable UV-B responses among the HPV types, further studies of interactions between UV-B and HPV need to consider the HPV type. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Virus Research
volume
Aug 6
pages
213 - 219
publisher
Elsevier
external identifiers
  • wos:000261047600006
  • pmid:18692100
  • scopus:53749083668
ISSN
1872-7492
DOI
10.1016/j.virusres.2008.07.013
language
English
LU publication?
yes
id
fb98fb40-ea01-4575-81cd-39c55edc7f19 (old id 1223361)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18692100?dopt=Abstract
date added to LUP
2016-04-04 08:54:20
date last changed
2022-01-29 07:34:13
@article{fb98fb40-ea01-4575-81cd-39c55edc7f19,
  abstract     = {{The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation activated HPV-8 but inhibited HPV-38 and HPV-93 whereas HPV-92 and 96 were not affected. As there are variable UV-B responses among the HPV types, further studies of interactions between UV-B and HPV need to consider the HPV type.}},
  author       = {{Vasiljevic, Natasa and Nielsen, Lone and Doherty, Geoff and Dillner, Joakim and Forslund, Ola and Norrild, Bodil}},
  issn         = {{1872-7492}},
  language     = {{eng}},
  pages        = {{213--219}},
  publisher    = {{Elsevier}},
  series       = {{Virus Research}},
  title        = {{Differences in transcriptional activity of cutaneous human papillomaviruses.}},
  url          = {{http://dx.doi.org/10.1016/j.virusres.2008.07.013}},
  doi          = {{10.1016/j.virusres.2008.07.013}},
  volume       = {{Aug 6}},
  year         = {{2008}},
}