Advanced

Substrates for intra-atrial and interatrial conduction in the atrial septum: anatomical study on 84 human hearts.

Platonov, Pyotr LU ; Mitrofanova, Lubov; Ivanov, Vitaly and Ho, Siew Yen (2008) In Heart Rhythm 5(8). p.1189-1195
Abstract
BACKGROUND: Technical developments in the management of atrial arrhythmias revived interest into the detailed knowledge of atrial anatomy. The atrial septum (AS), known for its complex structure, has been particularly difficult to study, and our knowledge of the muscular bundles providing routes for intra-atrial and interatrial conduction within the AS remains limited. OBJECTIVE: The purpose of this study was to describe myocardial arrangement within the AS and adjacent parts of atrial walls for delineation of possible substrates for interatrial and intra-atrial conduction. METHODS: Human heart specimens from 84 postmortem studies were studied using conventional morphometric assessment, blunt dissection, and light microscopy of serial... (More)
BACKGROUND: Technical developments in the management of atrial arrhythmias revived interest into the detailed knowledge of atrial anatomy. The atrial septum (AS), known for its complex structure, has been particularly difficult to study, and our knowledge of the muscular bundles providing routes for intra-atrial and interatrial conduction within the AS remains limited. OBJECTIVE: The purpose of this study was to describe myocardial arrangement within the AS and adjacent parts of atrial walls for delineation of possible substrates for interatrial and intra-atrial conduction. METHODS: Human heart specimens from 84 postmortem studies were studied using conventional morphometric assessment, blunt dissection, and light microscopy of serial histological sections of AS. RESULTS: Interatrial muscular connections are present anteriorly, posteriorly between right pulmonary veins, and inferiorly between the coronary sinus and the right inferior pulmonary vein. The inferior connections can be more prominent than the Bachmann bundle. Atrial musculature in the fossa ovalis consists of muscular bands isolated by fatty tissue from the endocardium of the right and left atrium. They are arranged along the anterior-posterior axis and have connections with left atrial myocardium. Myocardial fascicles in the posterior-inferior and superior portions of the muscular rim of fossa ovalis originate on the right atrial side and can be traced toward the atrioventricular node. CONCLUSION: The general myocardial arrangement in the AS and adjacent regions of atrial walls are important for understanding propagation of atrial activation for selection of the optimal treatment strategy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heart Rhythm
volume
5
issue
8
pages
1189 - 1195
publisher
Elsevier
external identifiers
  • wos:000258550800017
  • pmid:18675231
  • scopus:50949095872
ISSN
1547-5271
DOI
10.1016/j.hrthm.2008.04.025
language
English
LU publication?
yes
id
a49819bb-0231-489d-9d3a-c1569c9ee5f4 (old id 1223542)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18675231?dopt=Abstract
date added to LUP
2008-09-10 11:48:21
date last changed
2017-07-30 04:51:02
@article{a49819bb-0231-489d-9d3a-c1569c9ee5f4,
  abstract     = {BACKGROUND: Technical developments in the management of atrial arrhythmias revived interest into the detailed knowledge of atrial anatomy. The atrial septum (AS), known for its complex structure, has been particularly difficult to study, and our knowledge of the muscular bundles providing routes for intra-atrial and interatrial conduction within the AS remains limited. OBJECTIVE: The purpose of this study was to describe myocardial arrangement within the AS and adjacent parts of atrial walls for delineation of possible substrates for interatrial and intra-atrial conduction. METHODS: Human heart specimens from 84 postmortem studies were studied using conventional morphometric assessment, blunt dissection, and light microscopy of serial histological sections of AS. RESULTS: Interatrial muscular connections are present anteriorly, posteriorly between right pulmonary veins, and inferiorly between the coronary sinus and the right inferior pulmonary vein. The inferior connections can be more prominent than the Bachmann bundle. Atrial musculature in the fossa ovalis consists of muscular bands isolated by fatty tissue from the endocardium of the right and left atrium. They are arranged along the anterior-posterior axis and have connections with left atrial myocardium. Myocardial fascicles in the posterior-inferior and superior portions of the muscular rim of fossa ovalis originate on the right atrial side and can be traced toward the atrioventricular node. CONCLUSION: The general myocardial arrangement in the AS and adjacent regions of atrial walls are important for understanding propagation of atrial activation for selection of the optimal treatment strategy.},
  author       = {Platonov, Pyotr and Mitrofanova, Lubov and Ivanov, Vitaly and Ho, Siew Yen},
  issn         = {1547-5271},
  language     = {eng},
  number       = {8},
  pages        = {1189--1195},
  publisher    = {Elsevier},
  series       = {Heart Rhythm},
  title        = {Substrates for intra-atrial and interatrial conduction in the atrial septum: anatomical study on 84 human hearts.},
  url          = {http://dx.doi.org/10.1016/j.hrthm.2008.04.025},
  volume       = {5},
  year         = {2008},
}