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Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.

Elfving, Maria LU ; Svensson, Johan LU ; Oikarinen, Sami; Jonsson, Björn; Olofsson, Per; Sundkvist, Göran LU ; Lindberg, Bengt LU ; Lernmark, Åke LU ; Hyöty, Heikki and Ivarsson, Sten LU (2008) In Experimental Diabetes Research 2008.
Abstract
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for... (More)
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Diabetes Research
volume
2008
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000267260800001
  • pmid:18670622
  • scopus:56149127682
ISSN
1687-5214
DOI
10.1155/2008/271958
language
English
LU publication?
yes
id
86f3c591-ced8-4cac-b57a-277860fa8549 (old id 1223606)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18670622?dopt=Abstract
date added to LUP
2008-09-11 13:22:42
date last changed
2017-10-22 04:53:06
@article{86f3c591-ced8-4cac-b57a-277860fa8549,
  abstract     = {Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P &lt; .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.},
  articleno    = {271958},
  author       = {Elfving, Maria and Svensson, Johan and Oikarinen, Sami and Jonsson, Björn and Olofsson, Per and Sundkvist, Göran and Lindberg, Bengt and Lernmark, Åke and Hyöty, Heikki and Ivarsson, Sten},
  issn         = {1687-5214},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Experimental Diabetes Research},
  title        = {Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.},
  url          = {http://dx.doi.org/10.1155/2008/271958},
  volume       = {2008},
  year         = {2008},
}