Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
(2008) In Experimental Diabetes Research 2008.- Abstract
- Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for... (More)
- Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1223606
- author
- Elfving, Maria LU ; Svensson, Johan LU ; Oikarinen, Sami ; Jonsson, Björn ; Olofsson, Per ; Sundkvist, Göran LU ; Lindberg, Bengt LU ; Lernmark, Åke LU ; Hyöty, Heikki and Ivarsson, Sten LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Diabetes Research
- volume
- 2008
- article number
- 271958
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000267260800001
- pmid:18670622
- scopus:56149127682
- pmid:18670622
- ISSN
- 1687-5214
- DOI
- 10.1155/2008/271958
- language
- English
- LU publication?
- yes
- id
- 86f3c591-ced8-4cac-b57a-277860fa8549 (old id 1223606)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18670622?dopt=Abstract
- date added to LUP
- 2016-04-04 07:56:59
- date last changed
- 2022-01-29 02:49:07
@article{86f3c591-ced8-4cac-b57a-277860fa8549, abstract = {{Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.}}, author = {{Elfving, Maria and Svensson, Johan and Oikarinen, Sami and Jonsson, Björn and Olofsson, Per and Sundkvist, Göran and Lindberg, Bengt and Lernmark, Åke and Hyöty, Heikki and Ivarsson, Sten}}, issn = {{1687-5214}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{Experimental Diabetes Research}}, title = {{Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.}}, url = {{http://dx.doi.org/10.1155/2008/271958}}, doi = {{10.1155/2008/271958}}, volume = {{2008}}, year = {{2008}}, }