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Aniline in hydrolyzed urine and plasma--possible biomarkers for phenylisocyanate exposure.

Tinnerberg, Håkan LU ; Sennbro, Carl Johan LU and Jönsson, Bo A LU (2008) In Journal of Occupational and Environmental Hygiene2004-01-01+01:00 5(10). p.629-632
Abstract
There are few studies on phenylisocyanate (PhI) exposure, although there are studies indicating that PhI is a very potent chemical sensitizer. The aim of this study was to evaluate aniline in urine and plasma as possible biomarkers of exposure to PhI. Occupational airborne exposure to PhI was measured during one day for 11 workers exposed to thermal degradation products from polyurethane with filters impregnated with 2-methoxyphenyl piperazine. A urine sample was collected from each worker on measurement day, and plasma samples were collected within the following 2 weeks. Urine and plasma samples also were collected from four unexposed subjects. The biological samples were hydrolyzed and analyzed with gas chromatography mass spectrometry.... (More)
There are few studies on phenylisocyanate (PhI) exposure, although there are studies indicating that PhI is a very potent chemical sensitizer. The aim of this study was to evaluate aniline in urine and plasma as possible biomarkers of exposure to PhI. Occupational airborne exposure to PhI was measured during one day for 11 workers exposed to thermal degradation products from polyurethane with filters impregnated with 2-methoxyphenyl piperazine. A urine sample was collected from each worker on measurement day, and plasma samples were collected within the following 2 weeks. Urine and plasma samples also were collected from four unexposed subjects. The biological samples were hydrolyzed and analyzed with gas chromatography mass spectrometry. The time-weighted averages (TWA) for the workers were between 0.1 and 1.6 microg/m3. Aniline levels in urine were in the same range for the exposed and unexposed workers, but there was a significant correlation between air and urinary levels (Pearson's correlation coefficient r = 0.518; p = 0.05). All exposed workers had higher levels in the plasma samples than the highest control, and there was a significant correlation between the plasma levels and measured air levels (r = 0.675; p = 0.008). The conclusion is that aniline in hydrolyzed urine and plasma are possible biomarkers of exposure to PhI, and that the plasma biomarker is more sensitive, at least at this rather low exposure. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Air Pollutants, Isocyanates: pharmacokinetics, Occupational: toxicity, Occupational: pharmacokinetics, Aniline Compounds: blood, Aniline Compounds: urine, Biological Markers: blood, Environmental Monitoring: methods, Biological Markers: urine, Isocyanates: toxicity, Smoking: metabolism
in
Journal of Occupational and Environmental Hygiene2004-01-01+01:00
volume
5
issue
10
pages
629 - 632
publisher
Taylor & Francis
external identifiers
  • wos:000258025500002
  • pmid:18666023
  • scopus:48349142944
ISSN
1545-9632
DOI
10.1080/15459620802275411
language
English
LU publication?
yes
id
56d65dd7-d7e0-4fe4-9560-35619259d69c (old id 1223687)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18666023?dopt=Abstract
date added to LUP
2008-09-10 11:28:13
date last changed
2017-01-01 06:23:54
@article{56d65dd7-d7e0-4fe4-9560-35619259d69c,
  abstract     = {There are few studies on phenylisocyanate (PhI) exposure, although there are studies indicating that PhI is a very potent chemical sensitizer. The aim of this study was to evaluate aniline in urine and plasma as possible biomarkers of exposure to PhI. Occupational airborne exposure to PhI was measured during one day for 11 workers exposed to thermal degradation products from polyurethane with filters impregnated with 2-methoxyphenyl piperazine. A urine sample was collected from each worker on measurement day, and plasma samples were collected within the following 2 weeks. Urine and plasma samples also were collected from four unexposed subjects. The biological samples were hydrolyzed and analyzed with gas chromatography mass spectrometry. The time-weighted averages (TWA) for the workers were between 0.1 and 1.6 microg/m3. Aniline levels in urine were in the same range for the exposed and unexposed workers, but there was a significant correlation between air and urinary levels (Pearson's correlation coefficient r = 0.518; p = 0.05). All exposed workers had higher levels in the plasma samples than the highest control, and there was a significant correlation between the plasma levels and measured air levels (r = 0.675; p = 0.008). The conclusion is that aniline in hydrolyzed urine and plasma are possible biomarkers of exposure to PhI, and that the plasma biomarker is more sensitive, at least at this rather low exposure.},
  author       = {Tinnerberg, Håkan and Sennbro, Carl Johan and Jönsson, Bo A},
  issn         = {1545-9632},
  keyword      = {Air Pollutants,Isocyanates: pharmacokinetics,Occupational: toxicity,Occupational: pharmacokinetics,Aniline Compounds: blood,Aniline Compounds: urine,Biological Markers: blood,Environmental Monitoring: methods,Biological Markers: urine,Isocyanates: toxicity,Smoking: metabolism},
  language     = {eng},
  number       = {10},
  pages        = {629--632},
  publisher    = {Taylor & Francis},
  series       = {Journal of Occupational and Environmental Hygiene2004-01-01+01:00},
  title        = {Aniline in hydrolyzed urine and plasma--possible biomarkers for phenylisocyanate exposure.},
  url          = {http://dx.doi.org/10.1080/15459620802275411},
  volume       = {5},
  year         = {2008},
}