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Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?

Dillner, Joakim LU and Brown, Darron R (2004) In Expert Reviews in Molecular Medicine 2004. p.1-21
Abstract
Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a prophylactic vaccine. Such a vaccine, if found to be effective, could reduce the need for cervical cancer screening and have a profound effect on the incidence of cervical and other anogenital cancers. This review begins by examining the basic biological and epidemiological principles relevant to the development of HPV preventative vaccines. It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection... (More)
Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a prophylactic vaccine. Such a vaccine, if found to be effective, could reduce the need for cervical cancer screening and have a profound effect on the incidence of cervical and other anogenital cancers. This review begins by examining the basic biological and epidemiological principles relevant to the development of HPV preventative vaccines. It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection and cervical cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Expert Reviews in Molecular Medicine
volume
2004
pages
1 - 21
publisher
Cambridge University Press
external identifiers
  • scopus:25444445722
ISSN
1462-3994
DOI
10.1017/S1462399404007653
language
English
LU publication?
yes
id
cef5ea0c-e006-4a40-aa90-df8d03dd3e2c (old id 122547)
date added to LUP
2007-07-24 14:16:32
date last changed
2017-08-06 04:33:11
@article{cef5ea0c-e006-4a40-aa90-df8d03dd3e2c,
  abstract     = {Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a prophylactic vaccine. Such a vaccine, if found to be effective, could reduce the need for cervical cancer screening and have a profound effect on the incidence of cervical and other anogenital cancers. This review begins by examining the basic biological and epidemiological principles relevant to the development of HPV preventative vaccines. It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection and cervical cancer.},
  author       = {Dillner, Joakim and Brown, Darron R},
  issn         = {1462-3994},
  language     = {eng},
  pages        = {1--21},
  publisher    = {Cambridge University Press},
  series       = {Expert Reviews in Molecular Medicine},
  title        = {Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?},
  url          = {http://dx.doi.org/10.1017/S1462399404007653},
  volume       = {2004},
  year         = {2004},
}