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LEPREL1, a novel ER and Golgi resident member of the Leprecan family.

Järnum, Sofia LU ; Kjellman, Christian LU ; Darabi, Anna LU ; Nilsson, Ingar LU ; Edvardsen, Klaus LU and Aman, Pierre (2004) In Biochemical and Biophysical Research Communications 317(2). p.342-351
Abstract
We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase α domain (P4Hα), and a... (More)
We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase α domain (P4Hα), and a C-terminal KDEL ER-retention motif. LEPREL1 is localized to the ER and Golgi network and over-expressing it affects normal protein disulfide isomerase staining patterns in the ER. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hydroxylase, TPR, Author Keywords: Protein disulfide isomerase, P4Hα, Liposarcoma
in
Biochemical and Biophysical Research Communications
volume
317
issue
2
pages
342 - 351
publisher
Elsevier
external identifiers
  • wos:000220922200007
  • pmid:15063763
  • scopus:1842531216
ISSN
1090-2104
DOI
10.1016/j.bbrc.2004.03.060
language
English
LU publication?
yes
id
1b436122-eefe-42e5-b42d-6703a2d121a5 (old id 122858)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15063763&dopt=Abstract
date added to LUP
2007-07-16 11:06:30
date last changed
2017-01-01 06:43:04
@article{1b436122-eefe-42e5-b42d-6703a2d121a5,
  abstract     = {We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase α domain (P4Hα), and a C-terminal KDEL ER-retention motif. LEPREL1 is localized to the ER and Golgi network and over-expressing it affects normal protein disulfide isomerase staining patterns in the ER.},
  author       = {Järnum, Sofia and Kjellman, Christian and Darabi, Anna and Nilsson, Ingar and Edvardsen, Klaus and Aman, Pierre},
  issn         = {1090-2104},
  keyword      = {Hydroxylase,TPR,Author Keywords: Protein disulfide isomerase,P4Hα,Liposarcoma},
  language     = {eng},
  number       = {2},
  pages        = {342--351},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {LEPREL1, a novel ER and Golgi resident member of the Leprecan family.},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2004.03.060},
  volume       = {317},
  year         = {2004},
}