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Five-Year Outcome of Cholinergic Treatment of Alzheimer's Disease: Early Response Predicts Prolonged Time until Nursing Home Placement, but Does Not Alter Life Expectancy.

Wallin, Åsa LU ; Gustafson, Lars LU ; Sjögren, Magnus; Wattmo, Carina LU and Minthon, Lennart LU (2004) In Dementia and Geriatric Cognitive Disorders 18(2). p.197-206
Abstract
Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at... (More)
Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Long-term treatment, Tacrine, Alzheimer's disease, Nursing home placement.
in
Dementia and Geriatric Cognitive Disorders
volume
18
issue
2
pages
197 - 206
publisher
Karger
external identifiers
  • wos:000223321800013
  • pmid:15211076
  • scopus:4344675187
ISSN
1420-8008
DOI
10.1159/000079201
language
English
LU publication?
yes
id
b3dd9b56-aa3d-4920-81fb-215fbf7f4d30 (old id 123981)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15211076&dopt=Abstract
http://www.karger.com/Article/FullText/79201
date added to LUP
2007-07-05 14:04:54
date last changed
2017-01-01 04:54:18
@article{b3dd9b56-aa3d-4920-81fb-215fbf7f4d30,
  abstract     = {Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline.},
  author       = {Wallin, Åsa and Gustafson, Lars and Sjögren, Magnus and Wattmo, Carina and Minthon, Lennart},
  issn         = {1420-8008},
  keyword      = {Long-term treatment,Tacrine,Alzheimer's disease,Nursing home placement.},
  language     = {eng},
  number       = {2},
  pages        = {197--206},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Five-Year Outcome of Cholinergic Treatment of Alzheimer's Disease: Early Response Predicts Prolonged Time until Nursing Home Placement, but Does Not Alter Life Expectancy.},
  url          = {http://dx.doi.org/10.1159/000079201},
  volume       = {18},
  year         = {2004},
}