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Intrauterine exposure to maternal enterovirus infection as a risk factor for development of autoimmune thyroiditis during childhood and adolescence.

Svensson, Johan LU ; Lindberg, Bengt LU ; Jonsson, Björn; Ericsson, Ulla-Britt; Olofsson, Per LU ; Hyöty, Heikki and Ivarsson, Sten LU (2004) In Thyroid 14(5). p.367-370
Abstract
Maternal intrauterine enterovirus infection during pregnancy increases the risk for the offspring to develop

type 1 diabetes mellitus. Type 1 diabetes mellitus and autoimmune thyroiditits (AIT) are closely linked. A common

pathogenetic factor is possible. The objective of this study was to investigate a possible association between

maternal enterovirus infection during pregnancy and the development of AIT in the offspring. Sera taken

at delivery from 31 mothers whose children subsequently developed AIT was analyzed for immunoglobulin

(Ig)A, IgG, and IgM antibodies against enterovirus, and compared to a control group comprising 233 randomly

selected maternal sera. Of the mothers whose... (More)
Maternal intrauterine enterovirus infection during pregnancy increases the risk for the offspring to develop

type 1 diabetes mellitus. Type 1 diabetes mellitus and autoimmune thyroiditits (AIT) are closely linked. A common

pathogenetic factor is possible. The objective of this study was to investigate a possible association between

maternal enterovirus infection during pregnancy and the development of AIT in the offspring. Sera taken

at delivery from 31 mothers whose children subsequently developed AIT was analyzed for immunoglobulin

(Ig)A, IgG, and IgM antibodies against enterovirus, and compared to a control group comprising 233 randomly

selected maternal sera. Of the mothers whose children developed AIT, 5 of 31 (16%) were enterovirus IgM-positive,

compared to 17 of 233 (7%) in the control group (p 5 0.16). The age at diagnosis of AIT was significantly

lower in the group of children with IgM-positive mothers compared to children with IgM-negative mothers

(p , 0.05). In addition, 3 children (60%) in the IgM-positive group were overtly hypothyroid at diagnosis of

AIT, compared to no child (0%) in the IgM-negative group (p , 0.01). No significant differences were found in

IgA and IgG antibody titers between the mothers whose children developed AIT and the control group. Although

this study did not have enough power to reveal intrauterine exposure to maternal enterovirus infection

during pregnancy as a risk factor for development of AIT during childhood and adolescence, it suggested

an association with earlier onset of clinical disease in children to enterovirus IgM-seropositive mothers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thyroid
volume
14
issue
5
pages
367 - 370
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:15186614
  • wos:000221775100007
  • scopus:2942616632
ISSN
1557-9077
DOI
10.1089/105072504774193203
language
English
LU publication?
yes
id
7f5b4d0e-94ed-406c-aec1-3d8399900800 (old id 124267)
date added to LUP
2007-07-30 14:57:09
date last changed
2017-04-30 13:13:56
@article{7f5b4d0e-94ed-406c-aec1-3d8399900800,
  abstract     = {Maternal intrauterine enterovirus infection during pregnancy increases the risk for the offspring to develop<br/><br>
type 1 diabetes mellitus. Type 1 diabetes mellitus and autoimmune thyroiditits (AIT) are closely linked. A common<br/><br>
pathogenetic factor is possible. The objective of this study was to investigate a possible association between<br/><br>
maternal enterovirus infection during pregnancy and the development of AIT in the offspring. Sera taken<br/><br>
at delivery from 31 mothers whose children subsequently developed AIT was analyzed for immunoglobulin<br/><br>
(Ig)A, IgG, and IgM antibodies against enterovirus, and compared to a control group comprising 233 randomly<br/><br>
selected maternal sera. Of the mothers whose children developed AIT, 5 of 31 (16%) were enterovirus IgM-positive,<br/><br>
compared to 17 of 233 (7%) in the control group (p 5 0.16). The age at diagnosis of AIT was significantly<br/><br>
lower in the group of children with IgM-positive mothers compared to children with IgM-negative mothers<br/><br>
(p , 0.05). In addition, 3 children (60%) in the IgM-positive group were overtly hypothyroid at diagnosis of<br/><br>
AIT, compared to no child (0%) in the IgM-negative group (p , 0.01). No significant differences were found in<br/><br>
IgA and IgG antibody titers between the mothers whose children developed AIT and the control group. Although<br/><br>
this study did not have enough power to reveal intrauterine exposure to maternal enterovirus infection<br/><br>
during pregnancy as a risk factor for development of AIT during childhood and adolescence, it suggested<br/><br>
an association with earlier onset of clinical disease in children to enterovirus IgM-seropositive mothers.},
  author       = {Svensson, Johan and Lindberg, Bengt and Jonsson, Björn and Ericsson, Ulla-Britt and Olofsson, Per and Hyöty, Heikki and Ivarsson, Sten},
  issn         = {1557-9077},
  language     = {eng},
  number       = {5},
  pages        = {367--370},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Thyroid},
  title        = {Intrauterine exposure to maternal enterovirus infection as a risk factor for development of autoimmune thyroiditis during childhood and adolescence.},
  url          = {http://dx.doi.org/10.1089/105072504774193203},
  volume       = {14},
  year         = {2004},
}