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Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis.

Vasiljevic, Natasa LU ; Hazard, Kristina LU ; Dillner, Joakim LU and Forslund, Ola LU (2008) In Journal of General Virology 89(Pt 10). p.2467-2474
Abstract
Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients... (More)
Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4-17.5), but the prevalence and viral loads were low. This characterization of HPV-107, -110 and -111 and FA75[KI88-03] expands the heterogeneity of members of species 2 of the genus Betapapillomavirus. However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of General Virology
volume
89
issue
Pt 10
pages
2467 - 2474
publisher
Society for General Microbiology
external identifiers
  • wos:000259829000012
  • pmid:18796715
  • scopus:54449098227
ISSN
1465-2099
DOI
10.1099/vir.0.2008/001925-0
language
English
LU publication?
yes
id
73547c10-489d-4764-a734-2b8a55d4af63 (old id 1242941)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18796715?dopt=Abstract
date added to LUP
2008-10-07 15:04:06
date last changed
2017-07-30 04:53:29
@article{73547c10-489d-4764-a734-2b8a55d4af63,
  abstract     = {Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus Betapapillomavirus, and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4-17.5), but the prevalence and viral loads were low. This characterization of HPV-107, -110 and -111 and FA75[KI88-03] expands the heterogeneity of members of species 2 of the genus Betapapillomavirus. However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive.},
  author       = {Vasiljevic, Natasa and Hazard, Kristina and Dillner, Joakim and Forslund, Ola},
  issn         = {1465-2099},
  language     = {eng},
  number       = {Pt 10},
  pages        = {2467--2474},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis.},
  url          = {http://dx.doi.org/10.1099/vir.0.2008/001925-0},
  volume       = {89},
  year         = {2008},
}