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Selective determination of acidic pharmaceuticals in wastewater using molecularly imprinted solid-phase extraction.

Zorita, Saioa LU ; Boyd, Brian; Jönsson, Stig; Yilmaz, Ecevit LU ; Svensson, Carin LU ; Mathiasson, Lennart LU and Bergström, Staffan LU (2008) In Analytica Chimica Acta 626(2). p.147-154
Abstract
The determination of acidic pharmaceuticals, such as non-steroidal anti-inflammatory drugs NSAIDs and clofibric acid (metabolite of clofibrate), at low ngL(-1) levels in wastewater requires highly selective and sensitive analytical procedures. The removal of matrix components during sample preparation results in significant benefits towards reducing the matrix effects during LC-MS analysis. Therefore this work describes a simple method to enrich and clean up NSAIDs and clofibric acid from sewage water using molecularly imprinted solid-phase extraction (MISPE). Final analysis was performed by liquid chromatography-tandem mass spectrometry. The performance of this method has been evaluated in fortified tap and sewage water in terms of... (More)
The determination of acidic pharmaceuticals, such as non-steroidal anti-inflammatory drugs NSAIDs and clofibric acid (metabolite of clofibrate), at low ngL(-1) levels in wastewater requires highly selective and sensitive analytical procedures. The removal of matrix components during sample preparation results in significant benefits towards reducing the matrix effects during LC-MS analysis. Therefore this work describes a simple method to enrich and clean up NSAIDs and clofibric acid from sewage water using molecularly imprinted solid-phase extraction (MISPE). Final analysis was performed by liquid chromatography-tandem mass spectrometry. The performance of this method has been evaluated in fortified tap and sewage water in terms of recovery, precision, linearity, and method quantification limit. Recovery for all compounds ranged in all matrices between 84 and 116% with intra-day R.S.D. values below 11.5%. Matrix effect evaluation demonstrated that even complex sample matrixes, such as pond or sewage water did not showed significant ion suppression/enhancement compared to tap water. The performance of the method was further emphasized by the study of pond water, which receives treated water from a sewage treatment plant in south Sweden. Raw sewage and treated water were also tested. In those samples, all acidic pharmaceuticals were detected in concentration above method quantification limits ranging from 5.1 to 5153.0ngL(-1). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Solid-phase extraction, Matrix effect, Molecularly imprinted polymers, Sewage water, Acidic pharmaceuticals
in
Analytica Chimica Acta
volume
626
issue
2
pages
147 - 154
publisher
Elsevier
external identifiers
  • wos:000259930700004
  • pmid:18790115
  • scopus:51449122971
ISSN
1873-4324
DOI
10.1016/j.aca.2008.07.051
language
English
LU publication?
yes
id
36a99835-aed1-4ae6-8e95-f5cd1381e569 (old id 1243022)
date added to LUP
2008-10-17 10:44:01
date last changed
2017-09-03 04:19:09
@article{36a99835-aed1-4ae6-8e95-f5cd1381e569,
  abstract     = {The determination of acidic pharmaceuticals, such as non-steroidal anti-inflammatory drugs NSAIDs and clofibric acid (metabolite of clofibrate), at low ngL(-1) levels in wastewater requires highly selective and sensitive analytical procedures. The removal of matrix components during sample preparation results in significant benefits towards reducing the matrix effects during LC-MS analysis. Therefore this work describes a simple method to enrich and clean up NSAIDs and clofibric acid from sewage water using molecularly imprinted solid-phase extraction (MISPE). Final analysis was performed by liquid chromatography-tandem mass spectrometry. The performance of this method has been evaluated in fortified tap and sewage water in terms of recovery, precision, linearity, and method quantification limit. Recovery for all compounds ranged in all matrices between 84 and 116% with intra-day R.S.D. values below 11.5%. Matrix effect evaluation demonstrated that even complex sample matrixes, such as pond or sewage water did not showed significant ion suppression/enhancement compared to tap water. The performance of the method was further emphasized by the study of pond water, which receives treated water from a sewage treatment plant in south Sweden. Raw sewage and treated water were also tested. In those samples, all acidic pharmaceuticals were detected in concentration above method quantification limits ranging from 5.1 to 5153.0ngL(-1).},
  author       = {Zorita, Saioa and Boyd, Brian and Jönsson, Stig and Yilmaz, Ecevit and Svensson, Carin and Mathiasson, Lennart and Bergström, Staffan},
  issn         = {1873-4324},
  keyword      = {Solid-phase extraction,Matrix effect,Molecularly imprinted polymers,Sewage water,Acidic pharmaceuticals},
  language     = {eng},
  number       = {2},
  pages        = {147--154},
  publisher    = {Elsevier},
  series       = {Analytica Chimica Acta},
  title        = {Selective determination of acidic pharmaceuticals in wastewater using molecularly imprinted solid-phase extraction.},
  url          = {http://dx.doi.org/10.1016/j.aca.2008.07.051},
  volume       = {626},
  year         = {2008},
}