Advanced

A multisubstrate deoxyribonucleoside kinase from plants.

Clausen, Anders Ranegaard LU ; Girandon, Lenart; Knecht, Wolfgang; Survery, Sabeen LU ; Andreasson, Erik LU ; Munch-Petersen, Birgitte and Piskur, Jure LU (2008) In Nucleic acids symposium series p.489-490
Abstract
Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic acids symposium series
issue
52
pages
489 - 490
publisher
Oxford University Press
external identifiers
  • scopus:78649428074
ISSN
1746-8272
DOI
10.1093/nass/nrn248
language
English
LU publication?
yes
id
44f84ba8-c69e-4ded-872e-538ec4b778af (old id 1243283)
date added to LUP
2008-11-06 12:16:01
date last changed
2017-01-01 05:53:06
@article{44f84ba8-c69e-4ded-872e-538ec4b778af,
  abstract     = {Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.},
  author       = {Clausen, Anders Ranegaard and Girandon, Lenart and Knecht, Wolfgang and Survery, Sabeen and Andreasson, Erik and Munch-Petersen, Birgitte and Piskur, Jure},
  issn         = {1746-8272},
  language     = {eng},
  number       = {52},
  pages        = {489--490},
  publisher    = {Oxford University Press},
  series       = {Nucleic acids symposium series},
  title        = {A multisubstrate deoxyribonucleoside kinase from plants.},
  url          = {http://dx.doi.org/10.1093/nass/nrn248},
  year         = {2008},
}