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A multisubstrate deoxyribonucleoside kinase from plants.

Clausen, Anders Ranegaard LU ; Girandon, Lenart ; Knecht, Wolfgang LU ; Survery, Sabeen LU ; Andreasson, Erik LU ; Munch-Petersen, Birgitte and Piskur, Jure LU (2008) In Nucleic acids symposium series p.489-490
Abstract
Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic acids symposium series
issue
52
pages
489 - 490
publisher
Oxford University Press
external identifiers
  • scopus:78649428074
  • pmid:18776467
ISSN
0261-3166
DOI
10.1093/nass/nrn248
language
English
LU publication?
yes
id
44f84ba8-c69e-4ded-872e-538ec4b778af (old id 1243283)
date added to LUP
2016-04-01 13:48:10
date last changed
2022-01-27 21:10:33
@article{44f84ba8-c69e-4ded-872e-538ec4b778af,
  abstract     = {{Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.}},
  author       = {{Clausen, Anders Ranegaard and Girandon, Lenart and Knecht, Wolfgang and Survery, Sabeen and Andreasson, Erik and Munch-Petersen, Birgitte and Piskur, Jure}},
  issn         = {{0261-3166}},
  language     = {{eng}},
  number       = {{52}},
  pages        = {{489--490}},
  publisher    = {{Oxford University Press}},
  series       = {{Nucleic acids symposium series}},
  title        = {{A multisubstrate deoxyribonucleoside kinase from plants.}},
  url          = {{http://dx.doi.org/10.1093/nass/nrn248}},
  doi          = {{10.1093/nass/nrn248}},
  year         = {{2008}},
}