Advanced

Nuclear factor of activated T-cells transcription factors in the vasculature: the good guys or the bad guys?

Berglund, Lisa LU ; Öhman, Jenny LU ; Zetterqvist, Anna LU and Gomez, Maria LU (2008) In Current Opinion in Lipidology 19(5). p.483-490
Abstract
PURPOSE OF REVIEW: The nuclear factor of activated T-cells (NFAT) proteins are a family of Ca/calcineurin-dependent transcription factors that were first characterized in T-lymphocytes as inducers of cytokine gene expression. Since then, NFAT proteins have been shown to play varied roles outside of the immune system, including in the cardiovascular system. Cells in the vessel wall display a diverse array of Ca signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis. RECENT FINDINGS: It is now clear that NFAT signaling is required for normal vascular patterning during... (More)
PURPOSE OF REVIEW: The nuclear factor of activated T-cells (NFAT) proteins are a family of Ca/calcineurin-dependent transcription factors that were first characterized in T-lymphocytes as inducers of cytokine gene expression. Since then, NFAT proteins have been shown to play varied roles outside of the immune system, including in the cardiovascular system. Cells in the vessel wall display a diverse array of Ca signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis. RECENT FINDINGS: It is now clear that NFAT signaling is required for normal vascular patterning during embryogenesis and for vascular endothelial growth factor-induced angiogenesis. The overall role of NFAT signaling in the vasculature, however, is less clear during adult life. This review aims to give an update on mechanisms that regulate NFAT activation in vascular cells, with an emphasis on the role of mitochondria and of upstream activators such as lipids and glucose. It also addresses recent work implicating NFAT proteins as mediators of vascular disease. SUMMARY: A better understanding of the NFAT-signaling pathway in the vasculature may open up an unexplored area for the development of new therapeutic approaches for treating vascular disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Lipidology
volume
19
issue
5
pages
483 - 490
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000259349800007
  • pmid:18769229
  • scopus:53549119929
ISSN
1473-6535
DOI
10.1097/MOL.0b013e32830dd545
language
English
LU publication?
yes
id
dfe79c0d-defa-4333-b919-66316261adfa (old id 1243420)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18769229?dopt=Abstract
date added to LUP
2008-10-03 15:34:30
date last changed
2017-08-20 04:36:37
@article{dfe79c0d-defa-4333-b919-66316261adfa,
  abstract     = {PURPOSE OF REVIEW: The nuclear factor of activated T-cells (NFAT) proteins are a family of Ca/calcineurin-dependent transcription factors that were first characterized in T-lymphocytes as inducers of cytokine gene expression. Since then, NFAT proteins have been shown to play varied roles outside of the immune system, including in the cardiovascular system. Cells in the vessel wall display a diverse array of Ca signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis. RECENT FINDINGS: It is now clear that NFAT signaling is required for normal vascular patterning during embryogenesis and for vascular endothelial growth factor-induced angiogenesis. The overall role of NFAT signaling in the vasculature, however, is less clear during adult life. This review aims to give an update on mechanisms that regulate NFAT activation in vascular cells, with an emphasis on the role of mitochondria and of upstream activators such as lipids and glucose. It also addresses recent work implicating NFAT proteins as mediators of vascular disease. SUMMARY: A better understanding of the NFAT-signaling pathway in the vasculature may open up an unexplored area for the development of new therapeutic approaches for treating vascular disease.},
  author       = {Berglund, Lisa and Öhman, Jenny and Zetterqvist, Anna and Gomez, Maria},
  issn         = {1473-6535},
  language     = {eng},
  number       = {5},
  pages        = {483--490},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Lipidology},
  title        = {Nuclear factor of activated T-cells transcription factors in the vasculature: the good guys or the bad guys?},
  url          = {http://dx.doi.org/10.1097/MOL.0b013e32830dd545},
  volume       = {19},
  year         = {2008},
}