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Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma

Kuźniacka, Alina; Mertens, Fredrik LU ; Strömbeck, Bodil LU ; Wiegant, Joop and Mandahl, Nils LU (2004) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 151(2). p.178-181
Abstract

Chordoma is a rare, low- to intermediate-grade malignant tumor involving the axial spine. Cytogenetic data on these tumors have been limited to 25 cases. The findings of clonal chromosome aberrations in five new cases are presented. One of these and two previously reported cases have been studied with multicolor combined binary ratio labeling fluorescence in situ hybridization (COBRA-FISH). The karyotypes were near-diploid, mostly with several numerical and structural aberrations. There were multiple imbalances, with loss of segments from 1p, 3p, 3q, 9p, and chromosome 10 seen in two to four of the seven cases. No clustering of breakpoints was seen and no recurrent recombination between chromosomes was detected. The findings are... (More)

Chordoma is a rare, low- to intermediate-grade malignant tumor involving the axial spine. Cytogenetic data on these tumors have been limited to 25 cases. The findings of clonal chromosome aberrations in five new cases are presented. One of these and two previously reported cases have been studied with multicolor combined binary ratio labeling fluorescence in situ hybridization (COBRA-FISH). The karyotypes were near-diploid, mostly with several numerical and structural aberrations. There were multiple imbalances, with loss of segments from 1p, 3p, 3q, 9p, and chromosome 10 seen in two to four of the seven cases. No clustering of breakpoints was seen and no recurrent recombination between chromosomes was detected. The findings are consistent with previous data and indicate that chordoma tumor development is associated with multiple, nonrandom losses including chromosome segments that are frequently involved in many other solid tumors.

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published
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keywords
Aged, Chordoma, Female, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Male, Middle Aged, Spinal Neoplasms, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
151
issue
2
pages
4 pages
publisher
Elsevier
external identifiers
  • wos:000221978800008
  • pmid:15172757
  • scopus:2542484454
ISSN
0165-4608
DOI
10.1016/j.cancergencyto.2003.09.015
language
English
LU publication?
yes
id
780a6acd-46d8-49e3-978d-386d116e133c (old id 124431)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15172757&dopt=Abstract
date added to LUP
2007-07-08 11:19:41
date last changed
2017-04-09 04:12:22
@article{780a6acd-46d8-49e3-978d-386d116e133c,
  abstract     = {<p>Chordoma is a rare, low- to intermediate-grade malignant tumor involving the axial spine. Cytogenetic data on these tumors have been limited to 25 cases. The findings of clonal chromosome aberrations in five new cases are presented. One of these and two previously reported cases have been studied with multicolor combined binary ratio labeling fluorescence in situ hybridization (COBRA-FISH). The karyotypes were near-diploid, mostly with several numerical and structural aberrations. There were multiple imbalances, with loss of segments from 1p, 3p, 3q, 9p, and chromosome 10 seen in two to four of the seven cases. No clustering of breakpoints was seen and no recurrent recombination between chromosomes was detected. The findings are consistent with previous data and indicate that chordoma tumor development is associated with multiple, nonrandom losses including chromosome segments that are frequently involved in many other solid tumors.</p>},
  author       = {Kuźniacka, Alina and Mertens, Fredrik and Strömbeck, Bodil and Wiegant, Joop and Mandahl, Nils},
  issn         = {0165-4608},
  keyword      = {Aged,Chordoma,Female,Humans,In Situ Hybridization, Fluorescence,Karyotyping,Male,Middle Aged,Spinal Neoplasms,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {178--181},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma},
  url          = {http://dx.doi.org/10.1016/j.cancergencyto.2003.09.015},
  volume       = {151},
  year         = {2004},
}