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Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: A nationwide study

Werner, Marten; Prytz, Hanne LU ; Ohlsson, Bodil LU ; Almer, Sven; Bjornsson, Einar; Bergquist, Annika; Wallerstedt, Sven; Sandberg-Gertzen, Hanna; Hultcrantz, Rolf and Sangfelt, Per, et al. (2008) In Scandinavian Journal of Gastroenterology 43(10). p.1232-1240
Abstract
Objective. Autoimmune hepatitis (AIH) is a chronic liver disease, which if untreated can lead to cirrhosis and hepatic failure. The aim of the study was to investigate the incidence, prevalence, diagnostic tradition and clinical initial presentation of AIH. Material and methods. Analyses were performed in 473 patients identified as having probable or definite AIH. Results. The incidence of AIH was 0.85/100,000 (95% CI 0.69-1.01) inhabitants, which is somewhat lower than reported previously. The point prevalence amounted to 10.7/100,000 (95% CI 8.8-13.1), and 76% of the cases were females. The age-related incidence curve was bimodal but men were found to have only one incidence peak in the late teens, whereas women had a peak after... (More)
Objective. Autoimmune hepatitis (AIH) is a chronic liver disease, which if untreated can lead to cirrhosis and hepatic failure. The aim of the study was to investigate the incidence, prevalence, diagnostic tradition and clinical initial presentation of AIH. Material and methods. Analyses were performed in 473 patients identified as having probable or definite AIH. Results. The incidence of AIH was 0.85/100,000 (95% CI 0.69-1.01) inhabitants, which is somewhat lower than reported previously. The point prevalence amounted to 10.7/100,000 (95% CI 8.8-13.1), and 76% of the cases were females. The age-related incidence curve was bimodal but men were found to have only one incidence peak in the late teens, whereas women had a peak after menopause. AIH was presented as a spectrum of clinical settings from detected en passant to acute liver failure. Almost 30% of patients already had liver cirrhosis at diagnosis. Autoantibodies indicative of AIH type 1 were found in 79% of cases. Other concomitant autoimmune diseases were frequently found (49%). Conclusions. The incidence and prevalence figures confirm that AIH is a fairly uncommon disease in the Swedish population. Symptoms at presentation were unspecific, but almost half of the patients were jaundiced, with around 30% having liver cirrhosis. The majority of Swedish AIH patients had AIH type 1. (Less)
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publication status
published
subject
keywords
initial, epidemiology, cirrhosis, ANA, autoimmune hepatitis, SMA, presentation
in
Scandinavian Journal of Gastroenterology
volume
43
issue
10
pages
1232 - 1240
publisher
Taylor & Francis
external identifiers
  • wos:000259318200011
  • scopus:52149113541
ISSN
1502-7708
DOI
10.1080/00365520802130183
language
English
LU publication?
yes
id
044443f0-efb8-4ce4-868d-e0dbf7a122f6 (old id 1246803)
date added to LUP
2008-11-17 15:36:29
date last changed
2017-09-17 06:10:53
@article{044443f0-efb8-4ce4-868d-e0dbf7a122f6,
  abstract     = {Objective. Autoimmune hepatitis (AIH) is a chronic liver disease, which if untreated can lead to cirrhosis and hepatic failure. The aim of the study was to investigate the incidence, prevalence, diagnostic tradition and clinical initial presentation of AIH. Material and methods. Analyses were performed in 473 patients identified as having probable or definite AIH. Results. The incidence of AIH was 0.85/100,000 (95% CI 0.69-1.01) inhabitants, which is somewhat lower than reported previously. The point prevalence amounted to 10.7/100,000 (95% CI 8.8-13.1), and 76% of the cases were females. The age-related incidence curve was bimodal but men were found to have only one incidence peak in the late teens, whereas women had a peak after menopause. AIH was presented as a spectrum of clinical settings from detected en passant to acute liver failure. Almost 30% of patients already had liver cirrhosis at diagnosis. Autoantibodies indicative of AIH type 1 were found in 79% of cases. Other concomitant autoimmune diseases were frequently found (49%). Conclusions. The incidence and prevalence figures confirm that AIH is a fairly uncommon disease in the Swedish population. Symptoms at presentation were unspecific, but almost half of the patients were jaundiced, with around 30% having liver cirrhosis. The majority of Swedish AIH patients had AIH type 1.},
  author       = {Werner, Marten and Prytz, Hanne and Ohlsson, Bodil and Almer, Sven and Bjornsson, Einar and Bergquist, Annika and Wallerstedt, Sven and Sandberg-Gertzen, Hanna and Hultcrantz, Rolf and Sangfelt, Per and Weiland, Ola and Danielsson, Ake},
  issn         = {1502-7708},
  keyword      = {initial,epidemiology,cirrhosis,ANA,autoimmune hepatitis,SMA,presentation},
  language     = {eng},
  number       = {10},
  pages        = {1232--1240},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: A nationwide study},
  url          = {http://dx.doi.org/10.1080/00365520802130183},
  volume       = {43},
  year         = {2008},
}