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Smoking impairs human papillomavirus (HPV) type 16 and 18 capsids antibody response following natural HPV infection

Simen-Kapeu, Aline ; Kataja, Vesa ; Yliskoski, Merja ; Syrjanen, Kari ; Dillner, Joakim LU ; Koskela, Pentti ; Paavonen, Jorma and Lehtinen, Matti (2008) In Scandinavian Journal of Infectious Diseases 40(9). p.745-751
Abstract
The natural history of oncogenic human papillomavirus (HPV) infections results from interactions of the virus, the host, and multiple cofactors. We studied the association between humoral immune response to HPV and smoking in 191 HPV infected women prospectively. Two follow-up samples (first and last) were analysed for serum cotinine levels, IgA and IgG antibodies to HPV16 and 18, and Chlamydia trachomatis using ELISA methods. HPV DNA analyses were also performed, and HPV16/18 antibodies were detectable in 23 of 40 (57.5%) HPV DNA-positive women. We performed age-stratified analyses and found that young smokers were less likely to develop HPV16/18 antibodies than non-smokers (OR: 0.2, 95% CI 0.0-0.9). Furthermore, they had a significantly... (More)
The natural history of oncogenic human papillomavirus (HPV) infections results from interactions of the virus, the host, and multiple cofactors. We studied the association between humoral immune response to HPV and smoking in 191 HPV infected women prospectively. Two follow-up samples (first and last) were analysed for serum cotinine levels, IgA and IgG antibodies to HPV16 and 18, and Chlamydia trachomatis using ELISA methods. HPV DNA analyses were also performed, and HPV16/18 antibodies were detectable in 23 of 40 (57.5%) HPV DNA-positive women. We performed age-stratified analyses and found that young smokers were less likely to develop HPV16/18 antibodies than non-smokers (OR: 0.2, 95% CI 0.0-0.9). Furthermore, they had a significantly decreased tendency of maintaining constant HPV16/18 IgG antibody positivity by the end of the follow-up (OR: 0.1, 95% CI 0.0-0.8). Smoking did not affect the development of HPV antibody responses in women over 30 y of age. Our results suggest that smoking may induce impaired antibody response in HPV16/18-infected young women. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
40
issue
9
pages
745 - 751
publisher
Informa Healthcare
external identifiers
  • wos:000258623800009
  • scopus:50549096652
  • pmid:19086247
ISSN
1651-1980
DOI
10.1080/00365540801995360
language
English
LU publication?
yes
id
7123c92a-687e-43cb-89d3-bcdf37da5b94 (old id 1249744)
date added to LUP
2016-04-01 14:03:04
date last changed
2022-04-22 01:06:15
@article{7123c92a-687e-43cb-89d3-bcdf37da5b94,
  abstract     = {{The natural history of oncogenic human papillomavirus (HPV) infections results from interactions of the virus, the host, and multiple cofactors. We studied the association between humoral immune response to HPV and smoking in 191 HPV infected women prospectively. Two follow-up samples (first and last) were analysed for serum cotinine levels, IgA and IgG antibodies to HPV16 and 18, and Chlamydia trachomatis using ELISA methods. HPV DNA analyses were also performed, and HPV16/18 antibodies were detectable in 23 of 40 (57.5%) HPV DNA-positive women. We performed age-stratified analyses and found that young smokers were less likely to develop HPV16/18 antibodies than non-smokers (OR: 0.2, 95% CI 0.0-0.9). Furthermore, they had a significantly decreased tendency of maintaining constant HPV16/18 IgG antibody positivity by the end of the follow-up (OR: 0.1, 95% CI 0.0-0.8). Smoking did not affect the development of HPV antibody responses in women over 30 y of age. Our results suggest that smoking may induce impaired antibody response in HPV16/18-infected young women.}},
  author       = {{Simen-Kapeu, Aline and Kataja, Vesa and Yliskoski, Merja and Syrjanen, Kari and Dillner, Joakim and Koskela, Pentti and Paavonen, Jorma and Lehtinen, Matti}},
  issn         = {{1651-1980}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{745--751}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Infectious Diseases}},
  title        = {{Smoking impairs human papillomavirus (HPV) type 16 and 18 capsids antibody response following natural HPV infection}},
  url          = {{http://dx.doi.org/10.1080/00365540801995360}},
  doi          = {{10.1080/00365540801995360}},
  volume       = {{40}},
  year         = {{2008}},
}