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Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study

Kupcinskas, Limas; Lafolie, Pierre; Lignell, Ake; Kiudelis, Gediminas; Jonaitis, Laimas; Adamonis, Kestutis; Andersen, Leif Percival and Wadström, Torkel LU (2008) In Phytomedicine 15(6-7). p.391-399
Abstract
Objectives: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. Design: The study was a controlled, prospective, randomized, and double blind trial. Participants: Patients with functional dyspepsia, divided into three groups with 44 individuals in each group (placebo, 16 mg, or 40 mg astaxanthin, respectively). Interventions: Participants were asked to accept gastroscopy before treatment, together with questionnaires: GSRS and SF-36. Urea breath test (UBT) was done before the treatment. Main outcome: The primary objective was to test the hypothesis that the antioxidant astaxanthin at two doses regimens compared to placebo should... (More)
Objectives: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. Design: The study was a controlled, prospective, randomized, and double blind trial. Participants: Patients with functional dyspepsia, divided into three groups with 44 individuals in each group (placebo, 16 mg, or 40 mg astaxanthin, respectively). Interventions: Participants were asked to accept gastroscopy before treatment, together with questionnaires: GSRS and SF-36. Urea breath test (UBT) was done before the treatment. Main outcome: The primary objective was to test the hypothesis that the antioxidant astaxanthin at two doses regimens compared to placebo should ameliorate gastrointestinal discomfort measured as GSRS in patients with functional dyspepsia, who were either positive or negative for Helicobacter pylori, after 4 weeks of treatment. Results: At the end of therapy (week 4) no difference between the three treatment groups was observed regarding mean Gastrointestinal Symptom Rating Scale (GSRS) scores of abdominal pain, indigestion and reflux syndromes. The same results were observed at the end of follow-up. However reduction of reflux syndrome before treatment to week 4 was significantly pronounced in the higher (40 mg) dose compared to the other treatment groups (16 mg and placebo, p = 0.04). Conclusion: In general, no curative effect of astaxanthin was found in functional dyspepsia patients. Significantly greater reduction of reflux symptoms were detected in patients treated with the highest dose of the natural antioxidant astaxanthin. The response was more pronounced in H. pylori-infected patients. (c) 2008 Elsevier GmbH. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
astaxanthin, antioxidant, prospective randomized, double blind and placebo-controlled study, functional dyspepsia with and without, Helicobacter pylori
in
Phytomedicine
volume
15
issue
6-7
pages
391 - 399
publisher
Urban & Fischer Verlag
external identifiers
  • wos:000258561700001
  • scopus:44749088415
ISSN
0944-7113
DOI
10.1016/j.phymed.2008.04.004
language
English
LU publication?
yes
id
7f174f92-c15e-4d43-9575-6185ad4a1cad (old id 1249782)
date added to LUP
2008-11-05 11:47:46
date last changed
2017-09-17 06:55:07
@article{7f174f92-c15e-4d43-9575-6185ad4a1cad,
  abstract     = {Objectives: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. Design: The study was a controlled, prospective, randomized, and double blind trial. Participants: Patients with functional dyspepsia, divided into three groups with 44 individuals in each group (placebo, 16 mg, or 40 mg astaxanthin, respectively). Interventions: Participants were asked to accept gastroscopy before treatment, together with questionnaires: GSRS and SF-36. Urea breath test (UBT) was done before the treatment. Main outcome: The primary objective was to test the hypothesis that the antioxidant astaxanthin at two doses regimens compared to placebo should ameliorate gastrointestinal discomfort measured as GSRS in patients with functional dyspepsia, who were either positive or negative for Helicobacter pylori, after 4 weeks of treatment. Results: At the end of therapy (week 4) no difference between the three treatment groups was observed regarding mean Gastrointestinal Symptom Rating Scale (GSRS) scores of abdominal pain, indigestion and reflux syndromes. The same results were observed at the end of follow-up. However reduction of reflux syndrome before treatment to week 4 was significantly pronounced in the higher (40 mg) dose compared to the other treatment groups (16 mg and placebo, p = 0.04). Conclusion: In general, no curative effect of astaxanthin was found in functional dyspepsia patients. Significantly greater reduction of reflux symptoms were detected in patients treated with the highest dose of the natural antioxidant astaxanthin. The response was more pronounced in H. pylori-infected patients. (c) 2008 Elsevier GmbH. All rights reserved.},
  author       = {Kupcinskas, Limas and Lafolie, Pierre and Lignell, Ake and Kiudelis, Gediminas and Jonaitis, Laimas and Adamonis, Kestutis and Andersen, Leif Percival and Wadström, Torkel},
  issn         = {0944-7113},
  keyword      = {astaxanthin,antioxidant,prospective randomized,double blind and placebo-controlled study,functional dyspepsia with and without,Helicobacter pylori},
  language     = {eng},
  number       = {6-7},
  pages        = {391--399},
  publisher    = {Urban & Fischer Verlag},
  series       = {Phytomedicine},
  title        = {Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study},
  url          = {http://dx.doi.org/10.1016/j.phymed.2008.04.004},
  volume       = {15},
  year         = {2008},
}