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Deep brain stimulation in Parkinson's disease following fetal nigral transplantation

Herzog, Jan; Pogarell, Oliver; Pinsker, Marcus O.; Kupsch, Andreas; Oertel, Wolfgang H.; Lindvall, Olle LU ; Deuschl, Guenther and Volkmann, Jens (2008) In Movement Disorders 23(9). p.1293-1296
Abstract
OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias.... (More)
OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop. (C) 2008 Movement Disorder Society. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
deep brain stimulation, Parkinson's disease, neural transplantation, dyskinesias
in
Movement Disorders
volume
23
issue
9
pages
1293 - 1296
publisher
John Wiley & Sons
external identifiers
  • wos:000258421800016
  • scopus:52649157756
ISSN
0885-3185
DOI
10.1002/mds.21768
language
English
LU publication?
yes
id
24d34b73-cb9e-4208-a4c2-a2d1351ae092 (old id 1252738)
date added to LUP
2008-11-17 14:58:21
date last changed
2017-08-20 03:45:01
@article{24d34b73-cb9e-4208-a4c2-a2d1351ae092,
  abstract     = {OFF-period dyskinesias have been reported as a consequence of fetal nigral transplantation for Parkinson's disease. This type of dyskinesias may appear in patients even in the prolonged absence of antiparkinson medication and be aggravated by levodopa. Therefore, pharmacological therapeutic approaches in these patients are limited. Here we report two patients with bilateral fetal nigral grafts in the caudate and putamen subjected to deep brain stimulation (DBS) of the globus pallidus internus (GPi) or subthalamic nucleus (STN). Clinical assessment was performed according to UPDRS and the clinical dyskinesia rating scale. In both patients, we found significant improvement in OFF-period symptoms as well as levodopa-induced dyskinesias. However, only GPi-DBS led to a significant reduction of OFF-period dyskinesias whereas STN-DBS did not influence dyskinesias unrelated to external dopaminergic application. These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop. (C) 2008 Movement Disorder Society.},
  author       = {Herzog, Jan and Pogarell, Oliver and Pinsker, Marcus O. and Kupsch, Andreas and Oertel, Wolfgang H. and Lindvall, Olle and Deuschl, Guenther and Volkmann, Jens},
  issn         = {0885-3185},
  keyword      = {deep brain stimulation,Parkinson's disease,neural transplantation,dyskinesias},
  language     = {eng},
  number       = {9},
  pages        = {1293--1296},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Deep brain stimulation in Parkinson's disease following fetal nigral transplantation},
  url          = {http://dx.doi.org/10.1002/mds.21768},
  volume       = {23},
  year         = {2008},
}