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Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Gotmar, A.; Hammar, M.; Fredrikson, M.; Samsioe, Göran LU ; Nerbrand, Christina LU ; Lidfeldt, Jonas LU and Spetz, A. -C. (2008) In Climacteric 11(4). p.304-314
Abstract
Objectives The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Methods All women born in the period 1935-1945 and living in a defined geographic area in Sweden (n=10 766) were invited to a screening program that included physical and laboratory examinations and a questionnaire. Three groups were identified: premenopausal women, women on hormone replacement therapy (HRT) and postmenopausal women without HRT. Concentrations of testosterone, androstendione, sex hormone binding globulin and estradiol were measured. Waist-hip ratio, body mass index and free testosterone index (FTI) were... (More)
Objectives The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Methods All women born in the period 1935-1945 and living in a defined geographic area in Sweden (n=10 766) were invited to a screening program that included physical and laboratory examinations and a questionnaire. Three groups were identified: premenopausal women, women on hormone replacement therapy (HRT) and postmenopausal women without HRT. Concentrations of testosterone, androstendione, sex hormone binding globulin and estradiol were measured. Waist-hip ratio, body mass index and free testosterone index (FTI) were calculated. Results A total of 6908 women participated. The women on HRT had lower testosterone and FTI and were less satisfied with mood and energy (p < 0.05). Women with hot flushes had higher testosterone and FTI and women reporting coldness had lower concentrations (p < 0.05). Sexual well-being was not correlated to testosterone or FTI (p < 0.05). Conclusions Lower testosterone concentrations were associated with lower quality of life in perimenopausal women but not to sexual well-being. There must be factors other than decrements in sex hormones that contribute to the emergence of some perimenopausal symptoms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quality of life, androgens, testosterone, climacteric, perimenopause
in
Climacteric
volume
11
issue
4
pages
304 - 314
publisher
Taylor & Francis
external identifiers
  • wos:000257791400007
  • scopus:47749122168
ISSN
1369-7137
DOI
10.1080/13697130802249769
language
English
LU publication?
yes
id
e2295c98-141f-458c-b4bd-34e68bfbfd07 (old id 1253894)
date added to LUP
2008-11-04 09:44:33
date last changed
2017-05-21 03:46:33
@article{e2295c98-141f-458c-b4bd-34e68bfbfd07,
  abstract     = {Objectives The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Methods All women born in the period 1935-1945 and living in a defined geographic area in Sweden (n=10 766) were invited to a screening program that included physical and laboratory examinations and a questionnaire. Three groups were identified: premenopausal women, women on hormone replacement therapy (HRT) and postmenopausal women without HRT. Concentrations of testosterone, androstendione, sex hormone binding globulin and estradiol were measured. Waist-hip ratio, body mass index and free testosterone index (FTI) were calculated. Results A total of 6908 women participated. The women on HRT had lower testosterone and FTI and were less satisfied with mood and energy (p &lt; 0.05). Women with hot flushes had higher testosterone and FTI and women reporting coldness had lower concentrations (p &lt; 0.05). Sexual well-being was not correlated to testosterone or FTI (p &lt; 0.05). Conclusions Lower testosterone concentrations were associated with lower quality of life in perimenopausal women but not to sexual well-being. There must be factors other than decrements in sex hormones that contribute to the emergence of some perimenopausal symptoms.},
  author       = {Gotmar, A. and Hammar, M. and Fredrikson, M. and Samsioe, Göran and Nerbrand, Christina and Lidfeldt, Jonas and Spetz, A. -C.},
  issn         = {1369-7137},
  keyword      = {quality of life,androgens,testosterone,climacteric,perimenopause},
  language     = {eng},
  number       = {4},
  pages        = {304--314},
  publisher    = {Taylor & Francis},
  series       = {Climacteric},
  title        = {Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study},
  url          = {http://dx.doi.org/10.1080/13697130802249769},
  volume       = {11},
  year         = {2008},
}