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Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions

Pettersson, Gösta LU (1999) In Journal of Theoretical Biology 198(1). p.135-141
Abstract
Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Theoretical Biology
volume
198
issue
1
pages
135 - 141
publisher
Academic Press
external identifiers
  • scopus:0033532136
ISSN
1095-8541
DOI
10.1006/jtbi.1999.0904
language
English
LU publication?
yes
id
34ab10a3-472c-433e-9a34-e17509f0809b (old id 125393)
date added to LUP
2007-07-06 14:03:35
date last changed
2017-01-01 06:39:22
@article{34ab10a3-472c-433e-9a34-e17509f0809b,
  abstract     = {Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.},
  author       = {Pettersson, Gösta},
  issn         = {1095-8541},
  language     = {eng},
  number       = {1},
  pages        = {135--141},
  publisher    = {Academic Press},
  series       = {Journal of Theoretical Biology},
  title        = {Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions},
  url          = {http://dx.doi.org/10.1006/jtbi.1999.0904},
  volume       = {198},
  year         = {1999},
}