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Maternal use of thyroid hormones in pregnancy and neonatal outcome

Wikner, Birgitta Norstedt; Sparre, Lottie Skjoldebrand; Stiller, Carl-Olav; Källén, Bengt LU and Asker, Charlotte (2008) In Acta Obstetricia et Gynecologica Scandinavica 87(6). p.617-627
Abstract
Objective. To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. Design. Register study based on prospectively collected data in relation to delivery. Setting. Swedish Health Registers. Population. All pregnant women (n = 848,468) and all infants born (n = 861,989) in Sweden from 1 July 1995 to 31 December 2004. Methods. Women who reported the use of thyroid hormones in early pregnancy or obtained a prescription for thyroid hormones later in pregnancy (n = 9,866), as well as their infants (n = 10,055) were identified from the Swedish Medical Birth Register. The reference population consisted of all women... (More)
Objective. To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. Design. Register study based on prospectively collected data in relation to delivery. Setting. Swedish Health Registers. Population. All pregnant women (n = 848,468) and all infants born (n = 861,989) in Sweden from 1 July 1995 to 31 December 2004. Methods. Women who reported the use of thyroid hormones in early pregnancy or obtained a prescription for thyroid hormones later in pregnancy (n = 9,866), as well as their infants (n = 10,055) were identified from the Swedish Medical Birth Register. The reference population consisted of all women giving birth and their offspring during the same time interval. Main outcome measures. Neonatal outcome, malformations and maternal characteristics. Data were analyzed with adjustments for identified confounders. Results. Women using thyroxine had an increased rate of pre-eclampsia, diabetes (pre-existing or gestational), cesarean sections and inductions of labour compared to women in the reference population. The risk for preterm birth was marginally increased (OR 1.13, 95% CI 1.03-1.25). Neonatal thyroid disease was found in eight infants (seven with thyreotoxicosis and one unspecified), the expected number was 0.2. No further anomalies in neonatal diagnoses were found. A small but statistically significant risk for congenital malformations (OR = 1.14, 95% CI 1.05-1.26) was found. Conclusion. Women on thyroid substitution during pregnancy had an increased risk for some pregnancy complications, but their infants were only slightly affected. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thyroid hormone substitution, maternal outcome, malformations, neonatal outcome
in
Acta Obstetricia et Gynecologica Scandinavica
volume
87
issue
6
pages
617 - 627
publisher
Wiley-Blackwell
external identifiers
  • wos:000257910700006
  • scopus:45849126466
ISSN
1600-0412
DOI
10.1080/00016340802075103
language
English
LU publication?
yes
id
2df81595-a36b-4f35-9096-8cf9654176f7 (old id 1253984)
date added to LUP
2008-11-03 15:22:55
date last changed
2017-11-12 03:37:49
@article{2df81595-a36b-4f35-9096-8cf9654176f7,
  abstract     = {Objective. To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. Design. Register study based on prospectively collected data in relation to delivery. Setting. Swedish Health Registers. Population. All pregnant women (n = 848,468) and all infants born (n = 861,989) in Sweden from 1 July 1995 to 31 December 2004. Methods. Women who reported the use of thyroid hormones in early pregnancy or obtained a prescription for thyroid hormones later in pregnancy (n = 9,866), as well as their infants (n = 10,055) were identified from the Swedish Medical Birth Register. The reference population consisted of all women giving birth and their offspring during the same time interval. Main outcome measures. Neonatal outcome, malformations and maternal characteristics. Data were analyzed with adjustments for identified confounders. Results. Women using thyroxine had an increased rate of pre-eclampsia, diabetes (pre-existing or gestational), cesarean sections and inductions of labour compared to women in the reference population. The risk for preterm birth was marginally increased (OR 1.13, 95% CI 1.03-1.25). Neonatal thyroid disease was found in eight infants (seven with thyreotoxicosis and one unspecified), the expected number was 0.2. No further anomalies in neonatal diagnoses were found. A small but statistically significant risk for congenital malformations (OR = 1.14, 95% CI 1.05-1.26) was found. Conclusion. Women on thyroid substitution during pregnancy had an increased risk for some pregnancy complications, but their infants were only slightly affected.},
  author       = {Wikner, Birgitta Norstedt and Sparre, Lottie Skjoldebrand and Stiller, Carl-Olav and Källén, Bengt and Asker, Charlotte},
  issn         = {1600-0412},
  keyword      = {thyroid hormone substitution,maternal outcome,malformations,neonatal outcome},
  language     = {eng},
  number       = {6},
  pages        = {617--627},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Maternal use of thyroid hormones in pregnancy and neonatal outcome},
  url          = {http://dx.doi.org/10.1080/00016340802075103},
  volume       = {87},
  year         = {2008},
}