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Malignant lesions in the ventral prostate of alloxan-induced diabetic rats

Ribeiro, Daniele Lisboa; Marques, Silvio Fernando Guideti; Alberti, Sandra; Spadella, Cesar Tadeu; Manzato, Antonio Jose; Taboga, Sebastiao Roberto; Dizeyi, Nishtman; Abrahamsson, Per-Anders LU and Goes, Rejane Maira (2008) In International Journal of Experimental Pathology 89(4). p.276-283
Abstract
The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy;... (More)
The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy; and other rats showed premalignant and malignant lesions in the prostate. Such epithelial atrophy was, in some samples, combined with chronic inflammation, similar to proliferative inflammatory atrophy (PIA). The diabetic group also presented high incidence of prostatitis, adenocarcinoma and prostatic intra-epithelial neoplasia (PIN). Samples with adenocarcinoma had poorly differentiated acini with high levels of cellular proliferation and nuclear atypia. These lesions exhibited an invasive feature showing Bcl-2-positive cells and interruptions in the basement membrane. An association of PIA, PIN and adenocarcinoma was detected in one sample. Reduced androgen levels have a synergic effect to insulin dysfunction promoting negative effects in the rat prostate. Diabetic individuals had a high incidence of prostatitis, and this inflammation could stimulate the incidence of other forms of prostatic pathology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrophy, prostate, intra-epithelial neoplasia, inflammation, alloxan, diabetes
in
International Journal of Experimental Pathology
volume
89
issue
4
pages
276 - 283
publisher
Wiley-Blackwell
external identifiers
  • wos:000257756100006
  • scopus:47649105820
ISSN
0959-9673
DOI
10.1111/j.1365-2613.2008.00591.x
language
English
LU publication?
yes
id
439eb6dc-e72a-4233-8424-007d361e89f5 (old id 1254944)
date added to LUP
2008-10-17 15:00:24
date last changed
2017-09-17 05:22:27
@article{439eb6dc-e72a-4233-8424-007d361e89f5,
  abstract     = {The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy; and other rats showed premalignant and malignant lesions in the prostate. Such epithelial atrophy was, in some samples, combined with chronic inflammation, similar to proliferative inflammatory atrophy (PIA). The diabetic group also presented high incidence of prostatitis, adenocarcinoma and prostatic intra-epithelial neoplasia (PIN). Samples with adenocarcinoma had poorly differentiated acini with high levels of cellular proliferation and nuclear atypia. These lesions exhibited an invasive feature showing Bcl-2-positive cells and interruptions in the basement membrane. An association of PIA, PIN and adenocarcinoma was detected in one sample. Reduced androgen levels have a synergic effect to insulin dysfunction promoting negative effects in the rat prostate. Diabetic individuals had a high incidence of prostatitis, and this inflammation could stimulate the incidence of other forms of prostatic pathology.},
  author       = {Ribeiro, Daniele Lisboa and Marques, Silvio Fernando Guideti and Alberti, Sandra and Spadella, Cesar Tadeu and Manzato, Antonio Jose and Taboga, Sebastiao Roberto and Dizeyi, Nishtman and Abrahamsson, Per-Anders and Goes, Rejane Maira},
  issn         = {0959-9673},
  keyword      = {atrophy,prostate,intra-epithelial neoplasia,inflammation,alloxan,diabetes},
  language     = {eng},
  number       = {4},
  pages        = {276--283},
  publisher    = {Wiley-Blackwell},
  series       = {International Journal of Experimental Pathology},
  title        = {Malignant lesions in the ventral prostate of alloxan-induced diabetic rats},
  url          = {http://dx.doi.org/10.1111/j.1365-2613.2008.00591.x},
  volume       = {89},
  year         = {2008},
}