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Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects.

Liedman, Ragner LU ; Hansson, Stefan LU ; Howe, David; Igidbashian, Sarah; McLeod, Alison; Russell, Rachel J and Åkerlund, Mats LU (2008) In Gynecological Endocrinology 24(9). p.508-513
Abstract
The pathogenesis of primary dysmenorrhea is still poorly understood. The objective of the present investigation was to study differences in plasma concentrations of reproductive hormones in women with primary dysmenorrhea vs. healthy controls. In a prospective, parallel-group study we determined the plasma concentrations of oxytocin, vasopressin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol (17beta-E2), progesterone and prostaglandin F 2alpha metabolite (15-keto-13,14-dihydro-PGF 2alpha) over one menstrual cycle in eight women with primary dysmenorrhea and eight healthy volunteers. In dysmenorrheic women the plasma concentration of oxytocin was significantly higher at menstruation (p = 0.0084) and that of... (More)
The pathogenesis of primary dysmenorrhea is still poorly understood. The objective of the present investigation was to study differences in plasma concentrations of reproductive hormones in women with primary dysmenorrhea vs. healthy controls. In a prospective, parallel-group study we determined the plasma concentrations of oxytocin, vasopressin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol (17beta-E2), progesterone and prostaglandin F 2alpha metabolite (15-keto-13,14-dihydro-PGF 2alpha) over one menstrual cycle in eight women with primary dysmenorrhea and eight healthy volunteers. In dysmenorrheic women the plasma concentration of oxytocin was significantly higher at menstruation (p = 0.0084) and that of vasopressin significantly lower at ovulation (p = 0.0281) compared with healthy women. They had also higher FSH levels in the early follicular phase (p = 0.0087) and at menstruation (p = 0.0066) and the 17beta-E2 concentration was higher in the late follicular phase (p = 0.0449). No differences were seen for LH, progesterone and PGF 2alpha metabolite. The differences of oxytocin, vasopressin, FSH and 17beta-E2 concentrations found in plasma suggest an involvement of these hormones in mechanisms of primary dysmenorrhea. These mechanisms seem to be mainly regulated through the hypothalamus and pituitary. The influence of oxytocin on the non-pregnant uterus seems to be more important than earlier believed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gynecological Endocrinology
volume
24
issue
9
pages
508 - 513
publisher
Informa Healthcare
external identifiers
  • wos:000260457400009
  • pmid:18958771
  • scopus:55049099669
ISSN
0951-3590
DOI
10.1080/09513590802306218
language
English
LU publication?
yes
id
c4102f00-2742-4026-a127-7cd1cc4f1a23 (old id 1261825)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18958771?dopt=Abstract
date added to LUP
2008-11-04 12:15:21
date last changed
2017-02-05 04:32:35
@article{c4102f00-2742-4026-a127-7cd1cc4f1a23,
  abstract     = {The pathogenesis of primary dysmenorrhea is still poorly understood. The objective of the present investigation was to study differences in plasma concentrations of reproductive hormones in women with primary dysmenorrhea vs. healthy controls. In a prospective, parallel-group study we determined the plasma concentrations of oxytocin, vasopressin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol (17beta-E2), progesterone and prostaglandin F 2alpha metabolite (15-keto-13,14-dihydro-PGF 2alpha) over one menstrual cycle in eight women with primary dysmenorrhea and eight healthy volunteers. In dysmenorrheic women the plasma concentration of oxytocin was significantly higher at menstruation (p = 0.0084) and that of vasopressin significantly lower at ovulation (p = 0.0281) compared with healthy women. They had also higher FSH levels in the early follicular phase (p = 0.0087) and at menstruation (p = 0.0066) and the 17beta-E2 concentration was higher in the late follicular phase (p = 0.0449). No differences were seen for LH, progesterone and PGF 2alpha metabolite. The differences of oxytocin, vasopressin, FSH and 17beta-E2 concentrations found in plasma suggest an involvement of these hormones in mechanisms of primary dysmenorrhea. These mechanisms seem to be mainly regulated through the hypothalamus and pituitary. The influence of oxytocin on the non-pregnant uterus seems to be more important than earlier believed.},
  author       = {Liedman, Ragner and Hansson, Stefan and Howe, David and Igidbashian, Sarah and McLeod, Alison and Russell, Rachel J and Åkerlund, Mats},
  issn         = {0951-3590},
  language     = {eng},
  number       = {9},
  pages        = {508--513},
  publisher    = {Informa Healthcare},
  series       = {Gynecological Endocrinology},
  title        = {Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects.},
  url          = {http://dx.doi.org/10.1080/09513590802306218},
  volume       = {24},
  year         = {2008},
}