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GABA, a natural immunomodulator of T lymphocytes.

Bjurstöm, Helen; Wang, Junyang LU ; Ericsson, Ida LU ; Bengtsson, Martin; Liu, Yawei LU ; Kumar Mendu, Suresh LU ; Issazadeh, Shohreh LU and Birnir, Bryndis LU (2008) In Journal of Neuroimmunology 205(1-2). p.44-50
Abstract
gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T cell, Inhibition, GABAA, Tonic current
in
Journal of Neuroimmunology
volume
205
issue
1-2
pages
44 - 50
publisher
Elsevier
external identifiers
  • wos:000261902200008
  • pmid:18954912
  • scopus:56349109485
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2008.08.017
language
English
LU publication?
yes
id
c48d6f71-bcbc-4996-90f7-fb0f77138abe (old id 1261897)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18954912?dopt=Abstract
date added to LUP
2008-11-04 11:44:24
date last changed
2017-09-03 03:55:34
@article{c48d6f71-bcbc-4996-90f7-fb0f77138abe,
  abstract     = {gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.},
  author       = {Bjurstöm, Helen and Wang, Junyang and Ericsson, Ida and Bengtsson, Martin and Liu, Yawei and Kumar Mendu, Suresh and Issazadeh, Shohreh and Birnir, Bryndis},
  issn         = {1872-8421},
  keyword      = {T cell,Inhibition,GABAA,Tonic current},
  language     = {eng},
  number       = {1-2},
  pages        = {44--50},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {GABA, a natural immunomodulator of T lymphocytes.},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2008.08.017},
  volume       = {205},
  year         = {2008},
}