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GABA, a natural immunomodulator of T lymphocytes.

Bjurstöm, Helen ; Wang, Junyang LU ; Ericsson, Ida LU ; Bengtsson, Martin ; Liu, Yawei LU ; Kumar Mendu, Suresh LU ; Issazadeh, Shohreh LU and Birnir, Bryndis LU (2008) In Journal of Neuroimmunology 205(1-2). p.44-50
Abstract
gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T cell, Inhibition, GABAA, Tonic current
in
Journal of Neuroimmunology
volume
205
issue
1-2
pages
44 - 50
publisher
Elsevier
external identifiers
  • wos:000261902200008
  • pmid:18954912
  • scopus:56349109485
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2008.08.017
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroinflammation (013210006), GABA Channels in Physiology and Pharmacology (013241570)
id
c48d6f71-bcbc-4996-90f7-fb0f77138abe (old id 1261897)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18954912?dopt=Abstract
date added to LUP
2016-04-01 12:30:31
date last changed
2022-05-19 06:29:44
@article{c48d6f71-bcbc-4996-90f7-fb0f77138abe,
  abstract     = {{gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.}},
  author       = {{Bjurstöm, Helen and Wang, Junyang and Ericsson, Ida and Bengtsson, Martin and Liu, Yawei and Kumar Mendu, Suresh and Issazadeh, Shohreh and Birnir, Bryndis}},
  issn         = {{1872-8421}},
  keywords     = {{T cell; Inhibition; GABAA; Tonic current}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{44--50}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Neuroimmunology}},
  title        = {{GABA, a natural immunomodulator of T lymphocytes.}},
  url          = {{http://dx.doi.org/10.1016/j.jneuroim.2008.08.017}},
  doi          = {{10.1016/j.jneuroim.2008.08.017}},
  volume       = {{205}},
  year         = {{2008}},
}