GABA, a natural immunomodulator of T lymphocytes.
(2008) In Journal of Neuroimmunology 205(1-2). p.44-50- Abstract
- gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1261897
- author
- Bjurstöm, Helen ; Wang, Junyang LU ; Ericsson, Ida LU ; Bengtsson, Martin ; Liu, Yawei LU ; Kumar Mendu, Suresh LU ; Issazadeh, Shohreh LU and Birnir, Bryndis LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T cell, Inhibition, GABAA, Tonic current
- in
- Journal of Neuroimmunology
- volume
- 205
- issue
- 1-2
- pages
- 44 - 50
- publisher
- Elsevier
- external identifiers
-
- wos:000261902200008
- pmid:18954912
- scopus:56349109485
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2008.08.017
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroinflammation (013210006), GABA Channels in Physiology and Pharmacology (013241570)
- id
- c48d6f71-bcbc-4996-90f7-fb0f77138abe (old id 1261897)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18954912?dopt=Abstract
- date added to LUP
- 2016-04-01 12:30:31
- date last changed
- 2022-05-19 06:29:44
@article{c48d6f71-bcbc-4996-90f7-fb0f77138abe, abstract = {{gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.}}, author = {{Bjurstöm, Helen and Wang, Junyang and Ericsson, Ida and Bengtsson, Martin and Liu, Yawei and Kumar Mendu, Suresh and Issazadeh, Shohreh and Birnir, Bryndis}}, issn = {{1872-8421}}, keywords = {{T cell; Inhibition; GABAA; Tonic current}}, language = {{eng}}, number = {{1-2}}, pages = {{44--50}}, publisher = {{Elsevier}}, series = {{Journal of Neuroimmunology}}, title = {{GABA, a natural immunomodulator of T lymphocytes.}}, url = {{http://dx.doi.org/10.1016/j.jneuroim.2008.08.017}}, doi = {{10.1016/j.jneuroim.2008.08.017}}, volume = {{205}}, year = {{2008}}, }