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Operational tolerance in nonvascularized transplant models induced by AR-C117977, a monocarboxylate transporter inhibitor.

Paul, Clara LU ; Malm, Helene LU ; Qi, Zhongquan LU ; Veress, Bela LU ; Ferguson, Douglas; Bundick, Robert; Murray, Clare; Donald, David and Ekberg, Henrik LU (2008) In Transplantation 86(8). p.1135-1138
Abstract
AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study was performed in nonvascularized transplant models noted for their refractive response to standard immunosuppressive agents. Rat skin was transplanted from DA(RT1avl) into PVG(RT1c) and the reverse. Mouse islet allotransplantation was performed with BALB/c H2d donors and C57Bl/6J H2b recipients. In the skin graft model, AR-C117977 monotherapy was associated with long-term skin graft survival in one rat strain combination. AR-C117977 and cyclosporine A (CsA) in combination resulted in significant... (More)
AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study was performed in nonvascularized transplant models noted for their refractive response to standard immunosuppressive agents. Rat skin was transplanted from DA(RT1avl) into PVG(RT1c) and the reverse. Mouse islet allotransplantation was performed with BALB/c H2d donors and C57Bl/6J H2b recipients. In the skin graft model, AR-C117977 monotherapy was associated with long-term skin graft survival in one rat strain combination. AR-C117977 and cyclosporine A (CsA) in combination resulted in significant prolongation of graft survival in both rat strains. CsA monotherapy did not prevent acute rejection in either strain. Islet allograft survival was moderately prolonged with CsA or AR-C117977. AR-C117977 is an efficient immunosuppressive drug in stringent rodent transplant models and further studies are warranted. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Transplantation
volume
86
issue
8
pages
1135 - 1138
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000260554700018
  • pmid:18946353
  • scopus:55949131437
ISSN
1534-6080
DOI
10.1097/TP.0b013e318186b978
language
English
LU publication?
yes
id
d972bbbf-5efb-47f4-9ecf-a40147c1c483 (old id 1262024)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18946353?dopt=Abstract
date added to LUP
2008-11-04 10:42:37
date last changed
2017-01-01 07:49:03
@article{d972bbbf-5efb-47f4-9ecf-a40147c1c483,
  abstract     = {AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study was performed in nonvascularized transplant models noted for their refractive response to standard immunosuppressive agents. Rat skin was transplanted from DA(RT1avl) into PVG(RT1c) and the reverse. Mouse islet allotransplantation was performed with BALB/c H2d donors and C57Bl/6J H2b recipients. In the skin graft model, AR-C117977 monotherapy was associated with long-term skin graft survival in one rat strain combination. AR-C117977 and cyclosporine A (CsA) in combination resulted in significant prolongation of graft survival in both rat strains. CsA monotherapy did not prevent acute rejection in either strain. Islet allograft survival was moderately prolonged with CsA or AR-C117977. AR-C117977 is an efficient immunosuppressive drug in stringent rodent transplant models and further studies are warranted.},
  author       = {Paul, Clara and Malm, Helene and Qi, Zhongquan and Veress, Bela and Ferguson, Douglas and Bundick, Robert and Murray, Clare and Donald, David and Ekberg, Henrik},
  issn         = {1534-6080},
  language     = {eng},
  number       = {8},
  pages        = {1135--1138},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Transplantation},
  title        = {Operational tolerance in nonvascularized transplant models induced by AR-C117977, a monocarboxylate transporter inhibitor.},
  url          = {http://dx.doi.org/10.1097/TP.0b013e318186b978},
  volume       = {86},
  year         = {2008},
}