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Cancer therapy: targeting cell cycle regulators.

Johansson, Martin LU and Persson, Jenny L LU (2008) In Anti-Cancer Agents in Medicinal Chemistry 8(7). p.723-731
Abstract
Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their function may lead to the disruption of normal cell growth and apoptosis, and subsequently, result in carcinogenesis. Elevated levels of cyclins and CDKs are frequently observed in a wide range of different types of human cancers. Understanding of molecular mechanisms underlying the cell cycle effects in response to the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to chemotherapeutic agents. Despite the clinical applications of cell cycle specific chemotherapeutic agents, there is still an urgent need to develop novel drugs that can target multiple sites and pathways of... (More)
Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their function may lead to the disruption of normal cell growth and apoptosis, and subsequently, result in carcinogenesis. Elevated levels of cyclins and CDKs are frequently observed in a wide range of different types of human cancers. Understanding of molecular mechanisms underlying the cell cycle effects in response to the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to chemotherapeutic agents. Despite the clinical applications of cell cycle specific chemotherapeutic agents, there is still an urgent need to develop novel drugs that can target multiple sites and pathways of the cell cycle while avoiding drug induced cytotoxicity. In this review article, we will summarize the development of novel agents that specifically target cell cycle pathways in human cancer. We will discuss drugs that can directly interfere with the mitotic process of tumor cells. Moreover, we tend to address the significance of using small molecule CDK inhibitors that are derived from natural products. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anti-Cancer Agents in Medicinal Chemistry
volume
8
issue
7
pages
723 - 731
publisher
Bentham Science Publishers
external identifiers
  • wos:000259998500004
  • pmid:18855574
  • scopus:55249096300
ISSN
1875-5992
language
English
LU publication?
yes
id
a6488930-38ab-4037-8e0a-64e2afcacb6a (old id 1262192)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18855574?dopt=Abstract
date added to LUP
2008-11-03 13:15:34
date last changed
2017-05-21 04:31:40
@article{a6488930-38ab-4037-8e0a-64e2afcacb6a,
  abstract     = {Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their function may lead to the disruption of normal cell growth and apoptosis, and subsequently, result in carcinogenesis. Elevated levels of cyclins and CDKs are frequently observed in a wide range of different types of human cancers. Understanding of molecular mechanisms underlying the cell cycle effects in response to the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to chemotherapeutic agents. Despite the clinical applications of cell cycle specific chemotherapeutic agents, there is still an urgent need to develop novel drugs that can target multiple sites and pathways of the cell cycle while avoiding drug induced cytotoxicity. In this review article, we will summarize the development of novel agents that specifically target cell cycle pathways in human cancer. We will discuss drugs that can directly interfere with the mitotic process of tumor cells. Moreover, we tend to address the significance of using small molecule CDK inhibitors that are derived from natural products.},
  author       = {Johansson, Martin and Persson, Jenny L},
  issn         = {1875-5992},
  language     = {eng},
  number       = {7},
  pages        = {723--731},
  publisher    = {Bentham Science Publishers},
  series       = {Anti-Cancer Agents in Medicinal Chemistry},
  title        = {Cancer therapy: targeting cell cycle regulators.},
  volume       = {8},
  year         = {2008},
}