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Type 1 diabetes mellitus

Katsarou, Anastasia LU ; Gudbjörnsdottir, Soffia; Rawshani, Araz; Dabelea, Dana; Bonifacio, Ezio; Anderson, Barbara J.; Jacobsen, Laura Mary; Schatz, Desmond A. and Lernmark, Ake LU (2017) In Nature Reviews Disease Primers 3.
Abstract

Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8-all of which are proteins associated with secretory granules in β-cells-are biomarkers of T1DM-associated autoimmunity that are found... (More)

Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8-all of which are proteins associated with secretory granules in β-cells-are biomarkers of T1DM-associated autoimmunity that are found months to years before symptom onset, and can be used to identify and study individuals who are at risk of developing T1DM. The type of autoantibody that appears first depends on the environmental trigger and on genetic factors. The pathogenesis of T1DM can be divided into three stages depending on the absence or presence of hyperglycaemia and hyperglycaemia-associated symptoms (such as polyuria and thirst). A cure is not available, and patients depend on lifelong insulin injections; novel approaches to insulin treatment, such as insulin pumps, continuous glucose monitoring and hybrid closed-loop systems, are in development. Although intensive glycaemic control has reduced the incidence of microvascular and macrovascular complications, the majority of patients with T1DM are still developing these complications. Major research efforts are needed to achieve early diagnosis, prevent β-cell loss and develop better treatment options to improve the quality of life and prognosis of those affected.

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organization
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Contribution to journal
publication status
published
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in
Nature Reviews Disease Primers
volume
3
publisher
Nature Publishing Group
external identifiers
  • scopus:85016491752
  • wos:000397896100001
DOI
10.1038/nrdp.2017.16
language
English
LU publication?
yes
id
1262f6c6-3104-4f0a-a5fa-766ba01a67d0
date added to LUP
2017-04-26 15:09:37
date last changed
2017-09-18 13:33:23
@article{1262f6c6-3104-4f0a-a5fa-766ba01a67d0,
  abstract     = {<p>Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of β-cells. Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8-all of which are proteins associated with secretory granules in β-cells-are biomarkers of T1DM-associated autoimmunity that are found months to years before symptom onset, and can be used to identify and study individuals who are at risk of developing T1DM. The type of autoantibody that appears first depends on the environmental trigger and on genetic factors. The pathogenesis of T1DM can be divided into three stages depending on the absence or presence of hyperglycaemia and hyperglycaemia-associated symptoms (such as polyuria and thirst). A cure is not available, and patients depend on lifelong insulin injections; novel approaches to insulin treatment, such as insulin pumps, continuous glucose monitoring and hybrid closed-loop systems, are in development. Although intensive glycaemic control has reduced the incidence of microvascular and macrovascular complications, the majority of patients with T1DM are still developing these complications. Major research efforts are needed to achieve early diagnosis, prevent β-cell loss and develop better treatment options to improve the quality of life and prognosis of those affected.</p>},
  articleno    = {17016},
  author       = {Katsarou, Anastasia and Gudbjörnsdottir, Soffia and Rawshani, Araz and Dabelea, Dana and Bonifacio, Ezio and Anderson, Barbara J. and Jacobsen, Laura Mary and Schatz, Desmond A. and Lernmark, Ake},
  language     = {eng},
  month        = {03},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Disease Primers},
  title        = {Type 1 diabetes mellitus},
  url          = {http://dx.doi.org/10.1038/nrdp.2017.16},
  volume       = {3},
  year         = {2017},
}