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Gender Differences in Predictors of Heart Failure Morbidity and Mortality in an Urban Swedish Population: The Malmo Preventive Project

Tasevska, Gordana LU ; Kennedy, Linn LU ; Anevski, Dragi LU ; Nilsson, Peter LU ; Christensson, Anders LU and Willenheimer, Ronnie LU (2008) In Open Heart Failure Journal 1. p.1-8
Abstract
Objective/Background: Reports on heart failure (HF) predictors are scarce. We assessed gender-specific HF predictors.



Design: Preventive case-finding programme, register study.



Setting: City population-based sample.



Methods: We examined 33,342 HF-free subjects, 32.7% women, included in Malmo Preventive Project. Mean inclusion age was 49.7±7.4 years for women and 43.7±6.6 years for men.



Results: During 21.7±4.3 years of average follow-up, 764 (2.3%) subjects were diagnosed with HF, 120 (1.1%) women and 644 (2.9%) men. Following bootstrap analysis, the only strong independent predictor of HF among women was smoking. Independent predictors of HF among men were... (More)
Objective/Background: Reports on heart failure (HF) predictors are scarce. We assessed gender-specific HF predictors.



Design: Preventive case-finding programme, register study.



Setting: City population-based sample.



Methods: We examined 33,342 HF-free subjects, 32.7% women, included in Malmo Preventive Project. Mean inclusion age was 49.7±7.4 years for women and 43.7±6.6 years for men.



Results: During 21.7±4.3 years of average follow-up, 764 (2.3%) subjects were diagnosed with HF, 120 (1.1%) women and 644 (2.9%) men. Following bootstrap analysis, the only strong independent predictor of HF among women was smoking. Independent predictors of HF among men were diastolic blood pressure (BP), fasting blood-glucose, smoking, family history of myocardial infarction, and previous cardiovascular disease (CVD). During follow-up, 5,370 (16.1%) subjects died, 978 (9.0%) women and 4,392 (19.6%) men. Among both women and men, strong independent predictors of combined HF or all-cause death were high serum-triglycerides, fasting blood-glucose and estimated glomerular filtration rate, smoking, and previous CVD. Among men, also underweight, high BMI, and systolic and diastolic BP, were strong independent predictors of HF or death.



Conclusions: Although women and men shared many predictors of HF, there were several important differences between sexes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to specialist publication or newspaper
publication status
published
subject
keywords
Heart failure, mortality, predictors, men, women
categories
Popular Science
in
Open Heart Failure Journal
volume
1
pages
1 - 8
publisher
Bentham Open
ISSN
1876-5351
DOI
10.2174/1876535100801010001
language
English
LU publication?
yes
id
ede15cd0-b820-4120-ae28-cd52d360a62c (old id 1267649)
alternative location
http://www.benthamscience.com/open/tohfj/articles/V001/1TOHFJ.pdf
date added to LUP
2013-08-09 14:07:41
date last changed
2016-04-15 21:21:34
@misc{ede15cd0-b820-4120-ae28-cd52d360a62c,
  abstract     = {Objective/Background: Reports on heart failure (HF) predictors are scarce. We assessed gender-specific HF predictors.<br/><br>
<br/><br>
Design: Preventive case-finding programme, register study.<br/><br>
<br/><br>
Setting: City population-based sample.<br/><br>
<br/><br>
Methods: We examined 33,342 HF-free subjects, 32.7% women, included in Malmo Preventive Project. Mean inclusion age was 49.7±7.4 years for women and 43.7±6.6 years for men.<br/><br>
<br/><br>
Results: During 21.7±4.3 years of average follow-up, 764 (2.3%) subjects were diagnosed with HF, 120 (1.1%) women and 644 (2.9%) men. Following bootstrap analysis, the only strong independent predictor of HF among women was smoking. Independent predictors of HF among men were diastolic blood pressure (BP), fasting blood-glucose, smoking, family history of myocardial infarction, and previous cardiovascular disease (CVD). During follow-up, 5,370 (16.1%) subjects died, 978 (9.0%) women and 4,392 (19.6%) men. Among both women and men, strong independent predictors of combined HF or all-cause death were high serum-triglycerides, fasting blood-glucose and estimated glomerular filtration rate, smoking, and previous CVD. Among men, also underweight, high BMI, and systolic and diastolic BP, were strong independent predictors of HF or death.<br/><br>
<br/><br>
Conclusions: Although women and men shared many predictors of HF, there were several important differences between sexes.},
  author       = {Tasevska, Gordana and Kennedy, Linn and Anevski, Dragi and Nilsson, Peter and Christensson, Anders and Willenheimer, Ronnie},
  issn         = {1876-5351},
  keyword      = {Heart failure,mortality,predictors,men,women},
  language     = {eng},
  pages        = {1--8},
  publisher    = {Bentham Open},
  series       = {Open Heart Failure Journal},
  title        = {Gender Differences in Predictors of Heart Failure Morbidity and Mortality in an Urban Swedish Population: The Malmo Preventive Project},
  url          = {http://dx.doi.org/10.2174/1876535100801010001},
  volume       = {1},
  year         = {2008},
}