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The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS).

Isma, Nazim LU ; Breslin, Thomas LU ; Lindblad, Bengt LU and Svensson, Peter LU (2008) In Journal of Thrombosis and Thrombolysis Nov 21.
Abstract
The aim of this study was to investigate a relationship between FVL-mutation and levels of haemoglobin (Hb) in patients with venous thromboembolism (VTE). From March 1998 to December 2005, 927 consecutive patients with objectively diagnosed VTE were registered in the Malmö Thrombophilia Study (MATS). Female patients with FVL-mutation below 50 years of age had significantly higher median-Hb (133 vs. 126 g/l; P < 0.001) compared to female patients below the age of 50 years without FVL. No significant difference could be found for men or women above 50 years of age or men below 50 years of age. Female patients below the age of 50 years with FVL-mutation and VTE are associated with higher median Hb, and this finding is in accordance with... (More)
The aim of this study was to investigate a relationship between FVL-mutation and levels of haemoglobin (Hb) in patients with venous thromboembolism (VTE). From March 1998 to December 2005, 927 consecutive patients with objectively diagnosed VTE were registered in the Malmö Thrombophilia Study (MATS). Female patients with FVL-mutation below 50 years of age had significantly higher median-Hb (133 vs. 126 g/l; P < 0.001) compared to female patients below the age of 50 years without FVL. No significant difference could be found for men or women above 50 years of age or men below 50 years of age. Female patients below the age of 50 years with FVL-mutation and VTE are associated with higher median Hb, and this finding is in accordance with earlier hypothesis that FVL-mutation may have constituted an evolutionary selection advantage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Thrombolysis
volume
Nov 21
publisher
Springer
external identifiers
  • pmid:19023521
  • scopus:70349141003
ISSN
1573-742X
DOI
10.1007/s11239-008-0293-z
language
English
LU publication?
yes
id
ce8839f2-74b1-4e91-9449-830463e2afda (old id 1271244)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19023521?dopt=Abstract
date added to LUP
2008-12-04 16:04:37
date last changed
2017-01-01 07:46:50
@article{ce8839f2-74b1-4e91-9449-830463e2afda,
  abstract     = {The aim of this study was to investigate a relationship between FVL-mutation and levels of haemoglobin (Hb) in patients with venous thromboembolism (VTE). From March 1998 to December 2005, 927 consecutive patients with objectively diagnosed VTE were registered in the Malmö Thrombophilia Study (MATS). Female patients with FVL-mutation below 50 years of age had significantly higher median-Hb (133 vs. 126 g/l; P &lt; 0.001) compared to female patients below the age of 50 years without FVL. No significant difference could be found for men or women above 50 years of age or men below 50 years of age. Female patients below the age of 50 years with FVL-mutation and VTE are associated with higher median Hb, and this finding is in accordance with earlier hypothesis that FVL-mutation may have constituted an evolutionary selection advantage.},
  author       = {Isma, Nazim and Breslin, Thomas and Lindblad, Bengt and Svensson, Peter},
  issn         = {1573-742X},
  language     = {eng},
  publisher    = {Springer},
  series       = {Journal of Thrombosis and Thrombolysis},
  title        = {The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS).},
  url          = {http://dx.doi.org/10.1007/s11239-008-0293-z},
  volume       = {Nov 21},
  year         = {2008},
}