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White Monte Carlo for time-resolved photon migration.

Alerstam, Erik LU ; Andersson-Engels, Stefan LU and Svensson, Tomas LU (2008) In Journal of Biomedical Optics 13(4).
Abstract
A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating... (More)
A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering (mu(s)') and absorption (mu(a)). Experimental work supports our findings and establishes the advantages of Monte Carlo-based evaluation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biomedical Optics
volume
13
issue
4
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000259901000008
  • pmid:19021312
  • scopus:47249089915
ISSN
1083-3668
DOI
10.1117/1.2950319
language
English
LU publication?
yes
id
7b4b68fb-d248-4c1f-87d2-554f14b84f9c (old id 1271284)
date added to LUP
2009-01-16 14:30:16
date last changed
2017-11-19 03:28:08
@article{7b4b68fb-d248-4c1f-87d2-554f14b84f9c,
  abstract     = {A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering (mu(s)') and absorption (mu(a)). Experimental work supports our findings and establishes the advantages of Monte Carlo-based evaluation.},
  articleno    = {041304},
  author       = {Alerstam, Erik and Andersson-Engels, Stefan and Svensson, Tomas},
  issn         = {1083-3668},
  language     = {eng},
  number       = {4},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {White Monte Carlo for time-resolved photon migration.},
  url          = {http://dx.doi.org/10.1117/1.2950319},
  volume       = {13},
  year         = {2008},
}