White Monte Carlo for time-resolved photon migration.
(2008) In Journal of Biomedical Optics 13(4).- Abstract
- A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating... (More)
- A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering (mu(s)') and absorption (mu(a)). Experimental work supports our findings and establishes the advantages of Monte Carlo-based evaluation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1271284
- author
- Alerstam, Erik LU ; Andersson-Engels, Stefan LU and Svensson, Tomas LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomedical Optics
- volume
- 13
- issue
- 4
- article number
- 041304
- publisher
- SPIE
- external identifiers
-
- wos:000259901000008
- pmid:19021312
- scopus:47249089915
- ISSN
- 1083-3668
- DOI
- 10.1117/1.2950319
- language
- English
- LU publication?
- yes
- id
- 7b4b68fb-d248-4c1f-87d2-554f14b84f9c (old id 1271284)
- date added to LUP
- 2016-04-01 11:46:58
- date last changed
- 2022-03-13 00:39:29
@article{7b4b68fb-d248-4c1f-87d2-554f14b84f9c,
abstract = {{A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration--a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering (mu(s)') and absorption (mu(a)). Experimental work supports our findings and establishes the advantages of Monte Carlo-based evaluation.}},
author = {{Alerstam, Erik and Andersson-Engels, Stefan and Svensson, Tomas}},
issn = {{1083-3668}},
language = {{eng}},
number = {{4}},
publisher = {{SPIE}},
series = {{Journal of Biomedical Optics}},
title = {{White Monte Carlo for time-resolved photon migration.}},
url = {{https://lup.lub.lu.se/search/files/2639369/2368865.pdf}},
doi = {{10.1117/1.2950319}},
volume = {{13}},
year = {{2008}},
}