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Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.

Geng, Hui LU ; Carlsén, Stefan LU ; Kutty Selva, Nandakumar LU ; Holmdahl, Rikard LU ; Aspberg, Anders LU ; Oldberg, Åke LU and Mattsson, Ragnar LU (2008) In Arthritis Research and Therapy 10(6).
Abstract
ABSTRACT: INTRODUCTION: Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS: COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent... (More)
ABSTRACT: INTRODUCTION: Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS: COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent assay. RESULTS: COMP-deficient mice showed a significant early onset and increase in the severity of CIA in the chronic phase, whereas collagen II-antibody titers were similar in COMP-deficient and wild-type controls. COMP antibodies were not found in wild-type mice. Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. CONCLUSIONS: COMP deficiency enhances the early onset and development of chronic arthritis but does not affect collagen II autoimmunity. These findings accentuate the importance of COMP in cartilage stability. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
10
issue
6
publisher
BioMed Central
external identifiers
  • wos:000263570300020
  • pmid:19014566
  • scopus:57049178419
ISSN
1478-6362
DOI
10.1186/ar2551
language
English
LU publication?
yes
id
534c2456-2b6a-46b5-b72e-9b97cfac736e (old id 1271379)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19014566?dopt=Abstract
date added to LUP
2008-12-04 15:48:54
date last changed
2017-08-27 05:43:06
@article{534c2456-2b6a-46b5-b72e-9b97cfac736e,
  abstract     = {ABSTRACT: INTRODUCTION: Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS: COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent assay. RESULTS: COMP-deficient mice showed a significant early onset and increase in the severity of CIA in the chronic phase, whereas collagen II-antibody titers were similar in COMP-deficient and wild-type controls. COMP antibodies were not found in wild-type mice. Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. CONCLUSIONS: COMP deficiency enhances the early onset and development of chronic arthritis but does not affect collagen II autoimmunity. These findings accentuate the importance of COMP in cartilage stability.},
  articleno    = {R134},
  author       = {Geng, Hui and Carlsén, Stefan and Kutty Selva, Nandakumar and Holmdahl, Rikard and Aspberg, Anders and Oldberg, Åke and Mattsson, Ragnar},
  issn         = {1478-6362},
  language     = {eng},
  number       = {6},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.},
  url          = {http://dx.doi.org/10.1186/ar2551},
  volume       = {10},
  year         = {2008},
}