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Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.

Buchhave, Peder LU ; Janciauskiene, Sabina LU ; Zetterberg, Henrik; Blennow, Kaj; Minthon, Lennart LU and Hansson, Oskar LU (2009) In Neuroscience Letters 2008(Nov 6). p.56-59
Abstract
CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or... (More)
CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or developed vascular dementia during follow-up did not have significantly increased levels of sCD40 or sCD40L when compared to controls. The levels of sCD40 correlated to decreased baseline performance on mini-mental state examination (MMSE) in both controls (r(s)=-0.37, p<0.05) and MCI-AD cases (r(s)=-0.29, p<0.05). Finally, the plasma levels of sCD40 correlated with the levels of soluble amyloid precursor protein-alpha (sAPP-alpha) (r(s)=0.28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience Letters
volume
2008
issue
Nov 6
pages
56 - 59
publisher
Elsevier
external identifiers
  • wos:000263154500012
  • pmid:18996438
  • scopus:57549112723
ISSN
0304-3940
DOI
10.1016/j.neulet.2008.10.091
language
English
LU publication?
yes
id
852cf688-08fd-4052-ab36-74dd137f3fe2 (old id 1271654)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18996438?dopt=Abstract
date added to LUP
2008-12-03 13:08:51
date last changed
2017-02-26 03:40:04
@article{852cf688-08fd-4052-ab36-74dd137f3fe2,
  abstract     = {CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or developed vascular dementia during follow-up did not have significantly increased levels of sCD40 or sCD40L when compared to controls. The levels of sCD40 correlated to decreased baseline performance on mini-mental state examination (MMSE) in both controls (r(s)=-0.37, p&lt;0.05) and MCI-AD cases (r(s)=-0.29, p&lt;0.05). Finally, the plasma levels of sCD40 correlated with the levels of soluble amyloid precursor protein-alpha (sAPP-alpha) (r(s)=0.28, p&lt;0.01) and sAPP-beta (r(s)=0.23, p&lt;0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD.},
  author       = {Buchhave, Peder and Janciauskiene, Sabina and Zetterberg, Henrik and Blennow, Kaj and Minthon, Lennart and Hansson, Oskar},
  issn         = {0304-3940},
  language     = {eng},
  number       = {Nov 6},
  pages        = {56--59},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1016/j.neulet.2008.10.091},
  volume       = {2008},
  year         = {2009},
}