Advanced

Monoamine transporters in human endometrium and decidua.

Hansson, Stefan R; Bottalico, Barbara; Casslén, Vera LU and Casslén, Bertil LU (2009) In Human Reproduction Update 2008(Nov 5). p.249-260
Abstract
BACKGROUND Monoamines play important roles in decidualization, implantation, immune modulation and inflammation. Furthermore, monoamines are potent vasoactive mediators that regulate blood flow and capillary permeability. Regulation of the uterine blood flow is important both during menstruation and pregnancy. Adequate monoamine concentrations are essential for a proper implantation and physiological development of pregnancy. Unlike most transmitter substances, monoamines are recycled by monoamine transporters rather than enzymatically inactivated. Their intracellular fate is influenced by their lower affinity for inactivating enzymes than for vesicular transporters located in intracellular vesicles. Thus, cells are capable not only of... (More)
BACKGROUND Monoamines play important roles in decidualization, implantation, immune modulation and inflammation. Furthermore, monoamines are potent vasoactive mediators that regulate blood flow and capillary permeability. Regulation of the uterine blood flow is important both during menstruation and pregnancy. Adequate monoamine concentrations are essential for a proper implantation and physiological development of pregnancy. Unlike most transmitter substances, monoamines are recycled by monoamine transporters rather than enzymatically inactivated. Their intracellular fate is influenced by their lower affinity for inactivating enzymes than for vesicular transporters located in intracellular vesicles. Thus, cells are capable not only of recapturizing and degrading monoamines, but also of storing and releasing them in a controlled fashion. METHODS The general objective of the present review is to summarize the role of the monoamine transporters in the female human reproduction. Since the transporter proteins critically regulate extracellular monoamine concentrations, knowledge of their distribution and cyclic variation is of great importance for a deeper understanding of the contribution of monoaminergic mechanisms in the reproductive process. MEDLINE was searched for relevant publications from 1950 to 2007. RESULTS Two families of monoamine transporters, neuronal and extraneuronal monoamine transporters, are present in the human endometrium and deciduas. CONCLUSIONS New knowledge about monoamine metabolism in the endometrium during menstruation and pregnancy will increase understanding of infertility problems and may offer new pharmacological approaches to optimize assisted reproduction. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Reproduction Update
volume
2008
issue
Nov 5
pages
249 - 260
publisher
Oxford University Press
external identifiers
  • wos:000263163800009
  • pmid:18987100
  • scopus:60149092745
ISSN
1355-4786
DOI
10.1093/humupd/dmn048
language
English
LU publication?
yes
id
2d7f9e98-f517-4890-b6af-ef6cd5b65c14 (old id 1271799)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18987100?dopt=Abstract
date added to LUP
2008-12-03 12:37:25
date last changed
2017-08-06 03:51:10
@article{2d7f9e98-f517-4890-b6af-ef6cd5b65c14,
  abstract     = {BACKGROUND Monoamines play important roles in decidualization, implantation, immune modulation and inflammation. Furthermore, monoamines are potent vasoactive mediators that regulate blood flow and capillary permeability. Regulation of the uterine blood flow is important both during menstruation and pregnancy. Adequate monoamine concentrations are essential for a proper implantation and physiological development of pregnancy. Unlike most transmitter substances, monoamines are recycled by monoamine transporters rather than enzymatically inactivated. Their intracellular fate is influenced by their lower affinity for inactivating enzymes than for vesicular transporters located in intracellular vesicles. Thus, cells are capable not only of recapturizing and degrading monoamines, but also of storing and releasing them in a controlled fashion. METHODS The general objective of the present review is to summarize the role of the monoamine transporters in the female human reproduction. Since the transporter proteins critically regulate extracellular monoamine concentrations, knowledge of their distribution and cyclic variation is of great importance for a deeper understanding of the contribution of monoaminergic mechanisms in the reproductive process. MEDLINE was searched for relevant publications from 1950 to 2007. RESULTS Two families of monoamine transporters, neuronal and extraneuronal monoamine transporters, are present in the human endometrium and deciduas. CONCLUSIONS New knowledge about monoamine metabolism in the endometrium during menstruation and pregnancy will increase understanding of infertility problems and may offer new pharmacological approaches to optimize assisted reproduction.},
  author       = {Hansson, Stefan R and Bottalico, Barbara and Casslén, Vera and Casslén, Bertil},
  issn         = {1355-4786},
  language     = {eng},
  number       = {Nov 5},
  pages        = {249--260},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction Update},
  title        = {Monoamine transporters in human endometrium and decidua.},
  url          = {http://dx.doi.org/10.1093/humupd/dmn048},
  volume       = {2008},
  year         = {2009},
}