Nontypeable Haemophilus influenzae as a Pathogen in Children.
(2009) In Pediatric Infectious Disease Journal 28(1). p.43-48- Abstract
- Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of... (More)
- Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1276418
- author
- Murphy, Timothy ; Faden, Howard ; Bakaletz, Lauren ; Kyd, Jennelle ; Forsgren, Arne LU ; Campos, José LU ; Virji, Mumtaz and Pelton, Stephen
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Infectious Disease Journal
- volume
- 28
- issue
- 1
- pages
- 43 - 48
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000262247200011
- pmid:19057458
- scopus:65649084792
- ISSN
- 1532-0987
- DOI
- 10.1097/INF.0b013e318184dba2
- language
- English
- LU publication?
- yes
- id
- 31c02d38-b942-4947-9fdb-79d3bef48efb (old id 1276418)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19057458?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:52
- date last changed
- 2022-05-16 23:22:09
@article{31c02d38-b942-4947-9fdb-79d3bef48efb, abstract = {{Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H. influenzae type b conjugate vaccines have no effect on infections caused by nontypeable strains because nontypeable strains are nonencapsulated. Approximately, one-third of episodes of otitis media are caused by nontypeable H. influenzae and the bacterium is the most common cause of recurrent otitis media. Recent progress in elucidating molecular mechanisms of pathogenesis, understanding the role of biofilms in otitis media and an increasing understanding of immune responses have potential for development of novel strategies to improve prevention and treatment of otitis media caused by nontypeable H. influenzae. Feasibility of vaccination for prevention of otitis media due to nontypeable H. influenzae was recently demonstrated in a clinical trial with a vaccine that included the surface virulence factor, protein D.}}, author = {{Murphy, Timothy and Faden, Howard and Bakaletz, Lauren and Kyd, Jennelle and Forsgren, Arne and Campos, José and Virji, Mumtaz and Pelton, Stephen}}, issn = {{1532-0987}}, language = {{eng}}, number = {{1}}, pages = {{43--48}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Pediatric Infectious Disease Journal}}, title = {{Nontypeable Haemophilus influenzae as a Pathogen in Children.}}, url = {{http://dx.doi.org/10.1097/INF.0b013e318184dba2}}, doi = {{10.1097/INF.0b013e318184dba2}}, volume = {{28}}, year = {{2009}}, }