Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.
(2008) In Journal of Medicinal Chemistry 51(24). p.8109-8114- Abstract
- Aromatic 3,3'-diesters of thiodigalactoside were synthesized in a rapid three-step sequence from commercially available thiodigalactoside and evaluated as inhibitors of cancer- and immunity-related galectins. For each of galectins-1, -3, -7, and -9N-terminal domain, aromatic 3,3'-diesters of thiodigalactoside were found to have affinities in the low micromolar range, which represents a 7-70 fold enhancement over thiodigalactoside itself. No significant improvement was found for galectin-8 N-terminal domain. Two of the compounds were selected for testing in cell culture and were shown to have potent antimigratory effects on human PC-3 prostate and human A549 nonsmall-cell lung cancer cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1276489
- author
- Delaine, Tamara LU ; Cumpstey, Ian LU ; Ingrassia, Laurent ; Le Mercier, Marie ; Okechukwu, Paul LU ; Leffler, Hakon LU ; Kiss, Robert and Nilsson, Ulf LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Medicinal Chemistry
- volume
- 51
- issue
- 24
- pages
- 8109 - 8114
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000261876400047
- pmid:19053747
- scopus:58149100964
- ISSN
- 1520-4804
- DOI
- 10.1021/jm801077j
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Microbiology, Immunology and Glycobiology - MIG (013025200), Organic chemistry (S/LTH) (011001240)
- id
- a9d5e9eb-1dff-4b1c-8fc3-04d4d1f59855 (old id 1276489)
- date added to LUP
- 2016-04-01 11:56:16
- date last changed
- 2022-03-13 02:50:25
@article{a9d5e9eb-1dff-4b1c-8fc3-04d4d1f59855, abstract = {{Aromatic 3,3'-diesters of thiodigalactoside were synthesized in a rapid three-step sequence from commercially available thiodigalactoside and evaluated as inhibitors of cancer- and immunity-related galectins. For each of galectins-1, -3, -7, and -9N-terminal domain, aromatic 3,3'-diesters of thiodigalactoside were found to have affinities in the low micromolar range, which represents a 7-70 fold enhancement over thiodigalactoside itself. No significant improvement was found for galectin-8 N-terminal domain. Two of the compounds were selected for testing in cell culture and were shown to have potent antimigratory effects on human PC-3 prostate and human A549 nonsmall-cell lung cancer cells.}}, author = {{Delaine, Tamara and Cumpstey, Ian and Ingrassia, Laurent and Le Mercier, Marie and Okechukwu, Paul and Leffler, Hakon and Kiss, Robert and Nilsson, Ulf}}, issn = {{1520-4804}}, language = {{eng}}, number = {{24}}, pages = {{8109--8114}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of Medicinal Chemistry}}, title = {{Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.}}, url = {{http://dx.doi.org/10.1021/jm801077j}}, doi = {{10.1021/jm801077j}}, volume = {{51}}, year = {{2008}}, }