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Identification of novel candidate protein biomarkers for the post-polio syndrome — Implications for diagnosis, neurodegeneration and neuroinflammation

Gonzalez, Henrik; Ottervald, Jan; Nilsson, Kerstin C.; Sjögren, Niclas; Miliotis, Tasso; Von Bahr, Helena; Khademi, Mohsen; Eriksson, Bodil; Kjellström, Sven and Végvári, Ákos LU , et al. (2009) In Journal of Proteomics2008-01-01+01:00 71(6). p.670-681
Abstract

Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, a condition known as post-polio syndrome (PPS). The condition affects 20-60% of previous polio patients, making it one of the most common causes of neurological deficits worldwide. The underlying pathogenesis is not fully understood and accurate diagnosis is not feasible. Herein we investigated whether it was possible to identify proteomic profile aberrations in the cerebrospinal fluid (CSF) of PPS patients. CSF from 15 patients with well-defined PPS were analyzed for protein expression profiles. The results were compared to data obtained from nine healthy controls and 34 patients with other non-inflammatory diseases which served as... (More)

Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, a condition known as post-polio syndrome (PPS). The condition affects 20-60% of previous polio patients, making it one of the most common causes of neurological deficits worldwide. The underlying pathogenesis is not fully understood and accurate diagnosis is not feasible. Herein we investigated whether it was possible to identify proteomic profile aberrations in the cerebrospinal fluid (CSF) of PPS patients. CSF from 15 patients with well-defined PPS were analyzed for protein expression profiles. The results were compared to data obtained from nine healthy controls and 34 patients with other non-inflammatory diseases which served as negative controls. In addition, 17 samples from persons with secondary progressive multiple sclerosis (SPMS) were added as relevant age-matched references for the PPS samples. The CSF of persons with PPS displayed a disease-specific and highly predictive (p=0.0017) differential expression of five distinct proteins: gelsolin, hemopexin, peptidylglycine alpha-amidating monooxygenase, glutathione synthetase and kallikrein 6, respectively, in comparison with the control groups. An independent ELISA confirmed the increase of kallikrein 6. We suggest that these five proteins should be further evaluated as candidate biomarkers for the diagnosis and development of new therapies for PPS patients.

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published
subject
keywords
post-polio syndrome, CSF, proteomics, diagnosis, biomarkers, pathophysiology
in
Journal of Proteomics2008-01-01+01:00
volume
71
issue
6
pages
12 pages
publisher
Elsevier
external identifiers
  • wos:000263426500010
  • scopus:58649098959
ISSN
1874-3919
DOI
10.1016/j.jprot.2008.11.014
language
English
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yes
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7326e3ef-9c04-4708-88b5-28225107d663 (old id 1276756)
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2009-01-27 09:49:04
date last changed
2017-08-20 03:42:38
@article{7326e3ef-9c04-4708-88b5-28225107d663,
  abstract     = {<p>Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, a condition known as post-polio syndrome (PPS). The condition affects 20-60% of previous polio patients, making it one of the most common causes of neurological deficits worldwide. The underlying pathogenesis is not fully understood and accurate diagnosis is not feasible. Herein we investigated whether it was possible to identify proteomic profile aberrations in the cerebrospinal fluid (CSF) of PPS patients. CSF from 15 patients with well-defined PPS were analyzed for protein expression profiles. The results were compared to data obtained from nine healthy controls and 34 patients with other non-inflammatory diseases which served as negative controls. In addition, 17 samples from persons with secondary progressive multiple sclerosis (SPMS) were added as relevant age-matched references for the PPS samples. The CSF of persons with PPS displayed a disease-specific and highly predictive (p=0.0017) differential expression of five distinct proteins: gelsolin, hemopexin, peptidylglycine alpha-amidating monooxygenase, glutathione synthetase and kallikrein 6, respectively, in comparison with the control groups. An independent ELISA confirmed the increase of kallikrein 6. We suggest that these five proteins should be further evaluated as candidate biomarkers for the diagnosis and development of new therapies for PPS patients.</p>},
  author       = {Gonzalez, Henrik and Ottervald, Jan and Nilsson, Kerstin C. and Sjögren, Niclas and Miliotis, Tasso and Von Bahr, Helena and Khademi, Mohsen and Eriksson, Bodil and Kjellström, Sven and Végvári, Ákos and Harris, Robert and Marko-Varga, György and Borg, Kristian and Nilsson, Johan and Laurell, Thomas and Olsson, Tomas and Franzén, Bo},
  issn         = {1874-3919},
  keyword      = {post-polio syndrome,CSF,proteomics,diagnosis,biomarkers,pathophysiology},
  language     = {eng},
  number       = {6},
  pages        = {670--681},
  publisher    = {Elsevier},
  series       = {Journal of Proteomics2008-01-01+01:00},
  title        = {Identification of novel candidate protein biomarkers for the post-polio syndrome — Implications for diagnosis, neurodegeneration and neuroinflammation},
  url          = {http://dx.doi.org/10.1016/j.jprot.2008.11.014},
  volume       = {71},
  year         = {2009},
}