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Hand muscle pathology after long-term vibration exposure.

Necking, Lars LU ; Lundborg, Göran LU ; Lundström, Ronnie; Thornell, Lars-Eric and Fridén, Jan (2004) In Journal of Hand Surgery (British Volume) 29(5). p.431-437
Abstract
The morphology of the abductor pollicis brevis muscle was studied in 20 patients suffering from hand-arm vibration syndrome. The main morphological changes observed were centrally located myonuclei and fibre type grouping (found in all 20 muscle biopsies), angulated muscle fibres (found in 19 biopsies), ring fibres and regenerating fibres (found in 18 biopsies) and fibrosis (found in 17 biopsies). The observed abnormalities are believed to reflect damage to both the muscle fibres and the motor nerve. The changes were related to different vibration exposure parameters. The number of fibres demonstrating centrally located nuclei correlated significantly with the cumulative vibration exposure, while the number of angulated fibres correlated... (More)
The morphology of the abductor pollicis brevis muscle was studied in 20 patients suffering from hand-arm vibration syndrome. The main morphological changes observed were centrally located myonuclei and fibre type grouping (found in all 20 muscle biopsies), angulated muscle fibres (found in 19 biopsies), ring fibres and regenerating fibres (found in 18 biopsies) and fibrosis (found in 17 biopsies). The observed abnormalities are believed to reflect damage to both the muscle fibres and the motor nerve. The changes were related to different vibration exposure parameters. The number of fibres demonstrating centrally located nuclei correlated significantly with the cumulative vibration exposure, while the number of angulated fibres correlated significantly with the total vibration exposure time. This indicates that the vibrating tools may cause direct damage to muscle fibres as well as nerves. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exposure time, total vibration, hand-arm vibration syndrome, muscle pathology, tool acceleration, CVE
in
Journal of Hand Surgery (British Volume)
volume
29
issue
5
pages
431 - 437
publisher
SAGE Publications Inc.
external identifiers
  • wos:000224045800004
  • pmid:15336744
  • scopus:4444267737
ISSN
0266-7681
DOI
10.1016/j.jhsb.2004.05.004
language
English
LU publication?
yes
id
14f19e2a-71d1-4956-8e65-ca0ee218af17 (old id 127693)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15336744&dopt=Abstract
date added to LUP
2007-07-26 15:15:15
date last changed
2017-04-09 04:16:48
@article{14f19e2a-71d1-4956-8e65-ca0ee218af17,
  abstract     = {The morphology of the abductor pollicis brevis muscle was studied in 20 patients suffering from hand-arm vibration syndrome. The main morphological changes observed were centrally located myonuclei and fibre type grouping (found in all 20 muscle biopsies), angulated muscle fibres (found in 19 biopsies), ring fibres and regenerating fibres (found in 18 biopsies) and fibrosis (found in 17 biopsies). The observed abnormalities are believed to reflect damage to both the muscle fibres and the motor nerve. The changes were related to different vibration exposure parameters. The number of fibres demonstrating centrally located nuclei correlated significantly with the cumulative vibration exposure, while the number of angulated fibres correlated significantly with the total vibration exposure time. This indicates that the vibrating tools may cause direct damage to muscle fibres as well as nerves.},
  author       = {Necking, Lars and Lundborg, Göran and Lundström, Ronnie and Thornell, Lars-Eric and Fridén, Jan},
  issn         = {0266-7681},
  keyword      = {exposure time,total vibration,hand-arm vibration syndrome,muscle pathology,tool acceleration,CVE},
  language     = {eng},
  number       = {5},
  pages        = {431--437},
  publisher    = {SAGE Publications Inc.},
  series       = {Journal of Hand Surgery (British Volume)},
  title        = {Hand muscle pathology after long-term vibration exposure.},
  url          = {http://dx.doi.org/10.1016/j.jhsb.2004.05.004},
  volume       = {29},
  year         = {2004},
}