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A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Appendino, G; Della Porta, C; Conseil, G; Sterner, Olov LU ; Mercalli, E; Dumontet, C and Di Pietro, A (2003) In Journal of Natural Products 66(1). p.140-142
Abstract
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
66
issue
1
pages
140 - 142
publisher
The American Chemical Society
external identifiers
  • pmid:12542364
  • wos:000180623400031
  • scopus:12244266074
ISSN
0163-3864
DOI
10.1021/np0203537
language
English
LU publication?
yes
id
b20a1cbb-3995-4949-b1f3-33c58a47eb81 (old id 127884)
date added to LUP
2007-07-10 08:39:29
date last changed
2018-10-14 04:08:24
@article{b20a1cbb-3995-4949-b1f3-33c58a47eb81,
  abstract     = {The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.},
  author       = {Appendino, G and Della Porta, C and Conseil, G and Sterner, Olov and Mercalli, E and Dumontet, C and Di Pietro, A},
  issn         = {0163-3864},
  language     = {eng},
  number       = {1},
  pages        = {140--142},
  publisher    = {The American Chemical Society},
  series       = {Journal of Natural Products},
  title        = {A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).},
  url          = {http://dx.doi.org/10.1021/np0203537},
  volume       = {66},
  year         = {2003},
}