A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
(2003) In Journal of Natural Products 66(1). p.140-142- Abstract
- The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/127884
- author
- Appendino, G ; Della Porta, C ; Conseil, G ; Sterner, Olov LU ; Mercalli, E ; Dumontet, C and Di Pietro, A
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Natural Products
- volume
- 66
- issue
- 1
- pages
- 140 - 142
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:12542364
- wos:000180623400031
- scopus:12244266074
- ISSN
- 0163-3864
- DOI
- 10.1021/np0203537
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- b20a1cbb-3995-4949-b1f3-33c58a47eb81 (old id 127884)
- date added to LUP
- 2016-04-01 16:12:40
- date last changed
- 2022-04-22 20:25:43
@article{b20a1cbb-3995-4949-b1f3-33c58a47eb81, abstract = {{The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.}}, author = {{Appendino, G and Della Porta, C and Conseil, G and Sterner, Olov and Mercalli, E and Dumontet, C and Di Pietro, A}}, issn = {{0163-3864}}, language = {{eng}}, number = {{1}}, pages = {{140--142}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of Natural Products}}, title = {{A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).}}, url = {{http://dx.doi.org/10.1021/np0203537}}, doi = {{10.1021/np0203537}}, volume = {{66}}, year = {{2003}}, }