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K-ATP-channels and glucagon secretion glucose-regulated

Rorsman, Patrik LU ; Salehi, S Albert LU ; Abdulkader, Fernando; Braun, Matthias and MacDonald, Patrick E. (2008) In Trends in Endocrinology and Metabolism 19(8). p.277-284
Abstract
Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Endocrinology and Metabolism
volume
19
issue
8
pages
277 - 284
publisher
Elsevier
external identifiers
  • wos:000260444900002
  • scopus:52049105359
ISSN
1879-3061
DOI
10.1016/j.tem.2008.07.003
language
English
LU publication?
yes
id
2714f5a6-ddcf-48c2-9179-0d323ef5d330 (old id 1283754)
date added to LUP
2009-02-10 10:02:38
date last changed
2017-01-01 05:18:44
@article{2714f5a6-ddcf-48c2-9179-0d323ef5d330,
  abstract     = {Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.},
  author       = {Rorsman, Patrik and Salehi, S Albert and Abdulkader, Fernando and Braun, Matthias and MacDonald, Patrick E.},
  issn         = {1879-3061},
  language     = {eng},
  number       = {8},
  pages        = {277--284},
  publisher    = {Elsevier},
  series       = {Trends in Endocrinology and Metabolism},
  title        = {K-ATP-channels and glucagon secretion glucose-regulated},
  url          = {http://dx.doi.org/10.1016/j.tem.2008.07.003},
  volume       = {19},
  year         = {2008},
}