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Viruses as supramolecular self-assemblies: modelling of capsid formation and genome packaging

Angelescu, Daniel George and Linse, Per LU (2008) In Soft Matter 4(10). p.1981-1990
Abstract
Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on two vital aspects of the physics of viruses: viz. viral capsid self-assembly and viral genome packaging. Many processes, such as the self-assembly pathway, genome packing, and ultimately the infection mechanism, differ between viruses containing double-stranded polynucleotides on one hand and single-stranded polynucleotides on the other hand. We... (More)
Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on two vital aspects of the physics of viruses: viz. viral capsid self-assembly and viral genome packaging. Many processes, such as the self-assembly pathway, genome packing, and ultimately the infection mechanism, differ between viruses containing double-stranded polynucleotides on one hand and single-stranded polynucleotides on the other hand. We believe that these differences to a large degree originate from the different genome flexibilities. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
4
issue
10
pages
1981 - 1990
publisher
Royal Society of Chemistry
external identifiers
  • wos:000260377100004
  • scopus:52149092576
ISSN
1744-6848
DOI
10.1039/b802597e
language
English
LU publication?
yes
id
cf2c3abd-3503-4d59-8002-e4b25a4f7452 (old id 1283773)
date added to LUP
2009-02-10 10:06:19
date last changed
2017-07-30 04:08:27
@article{cf2c3abd-3503-4d59-8002-e4b25a4f7452,
  abstract     = {Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on two vital aspects of the physics of viruses: viz. viral capsid self-assembly and viral genome packaging. Many processes, such as the self-assembly pathway, genome packing, and ultimately the infection mechanism, differ between viruses containing double-stranded polynucleotides on one hand and single-stranded polynucleotides on the other hand. We believe that these differences to a large degree originate from the different genome flexibilities.},
  author       = {Angelescu, Daniel George and Linse, Per},
  issn         = {1744-6848},
  language     = {eng},
  number       = {10},
  pages        = {1981--1990},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Viruses as supramolecular self-assemblies: modelling of capsid formation and genome packaging},
  url          = {http://dx.doi.org/10.1039/b802597e},
  volume       = {4},
  year         = {2008},
}