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The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children

Nyman, Ulf LU ; Björk, Jonas LU ; Lindström, Veronica LU and Grubb, Anders LU (2008) In Scandinavian Journal of Clinical & Laboratory Investigation 68(7). p.568-576
Abstract
Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing <= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric... (More)
Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing <= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric creatinine equation, Counahan-Barratt (CB) and a cystatin C-based equation. Results . The MDRD equation performed poorly with a median bias of 96 %. Of the remaining equations, only the LM-LBM produced significant bias (+10 % in median) according to line of identity regression analysis. The LM equation yielded marginally higher accuracy (76 %) than the LM-LBM equation (74 %) and the CB (73 %), but lower than the cystatin C-based equation (82 %). However, the estimated accuracy figures for these four equations were generally imprecise and none of the differences compared with the LM equation was statistically significant. Conclusion . In contrast to most creatinine-based GFR prediction equations, the LM equation performs adequately for both children and adults. This may be due to the unique model-building principles used when the LM equation was established. Further validation in a larger paediatric population is necessary. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
kidney, kidney disease, Drug therapy, glomerular filtration rate, function tests, renal insufficiency
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
68
issue
7
pages
568 - 576
publisher
Informa Healthcare
external identifiers
  • wos:000260497100010
  • scopus:55249117793
ISSN
1502-7686
DOI
10.1080/00365510801915163
language
English
LU publication?
yes
id
82ea35ec-73f8-490e-a343-c03ae27964da (old id 1284115)
date added to LUP
2009-02-09 10:38:53
date last changed
2017-08-13 04:12:43
@article{82ea35ec-73f8-490e-a343-c03ae27964da,
  abstract     = {Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing &lt;= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric creatinine equation, Counahan-Barratt (CB) and a cystatin C-based equation. Results . The MDRD equation performed poorly with a median bias of 96 %. Of the remaining equations, only the LM-LBM produced significant bias (+10 % in median) according to line of identity regression analysis. The LM equation yielded marginally higher accuracy (76 %) than the LM-LBM equation (74 %) and the CB (73 %), but lower than the cystatin C-based equation (82 %). However, the estimated accuracy figures for these four equations were generally imprecise and none of the differences compared with the LM equation was statistically significant. Conclusion . In contrast to most creatinine-based GFR prediction equations, the LM equation performs adequately for both children and adults. This may be due to the unique model-building principles used when the LM equation was established. Further validation in a larger paediatric population is necessary.},
  author       = {Nyman, Ulf and Björk, Jonas and Lindström, Veronica and Grubb, Anders},
  issn         = {1502-7686},
  keyword      = {kidney,kidney disease,Drug therapy,glomerular filtration rate,function tests,renal insufficiency},
  language     = {eng},
  number       = {7},
  pages        = {568--576},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children},
  url          = {http://dx.doi.org/10.1080/00365510801915163},
  volume       = {68},
  year         = {2008},
}