The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children
Nyman, Ulf LU ; Björk, Jonas LU ; Lindström, Veronica LU
and Grubb, Anders
LU
(2008)
In Scandinavian Journal of Clinical & Laboratory Investigation
68(7).
p.568-576
- Abstract
- Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing <= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric... (More)
- Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing <= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric creatinine equation, Counahan-Barratt (CB) and a cystatin C-based equation. Results . The MDRD equation performed poorly with a median bias of 96 %. Of the remaining equations, only the LM-LBM produced significant bias (+10 % in median) according to line of identity regression analysis. The LM equation yielded marginally higher accuracy (76 %) than the LM-LBM equation (74 %) and the CB (73 %), but lower than the cystatin C-based equation (82 %). However, the estimated accuracy figures for these four equations were generally imprecise and none of the differences compared with the LM equation was statistically significant. Conclusion . In contrast to most creatinine-based GFR prediction equations, the LM equation performs adequately for both children and adults. This may be due to the unique model-building principles used when the LM equation was established. Further validation in a larger paediatric population is necessary. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1284115
- author
- Nyman, Ulf
LU
; Björk, Jonas
LU
; Lindström, Veronica
LU
and Grubb, Anders
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- kidney, kidney disease, Drug therapy, glomerular filtration rate, function tests, renal insufficiency
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 68
- issue
- 7
- pages
- 568 - 576
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000260497100010
- scopus:55249117793
- pmid:19378428
- ISSN
- 1502-7686
- DOI
- 10.1080/00365510801915163
- language
- English
- LU publication?
- yes
- id
- 82ea35ec-73f8-490e-a343-c03ae27964da (old id 1284115)
- date added to LUP
- 2016-04-01 15:05:27
- date last changed
- 2023-01-04 08:28:20
@article{82ea35ec-73f8-490e-a343-c03ae27964da,
abstract = {{Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one included lean body mass (LM-LBM). Comparisons focused on correlation (adjusted R-2), bias (median percent error) and accuracy (proportions of predicted GFR differing <= 30 % from measured GFR) (mL/min/1.73 m(2)). The performances were compared with those of the Modification of Diet in Renal Disease (MDRD) Study equation, a dedicated paediatric creatinine equation, Counahan-Barratt (CB) and a cystatin C-based equation. Results . The MDRD equation performed poorly with a median bias of 96 %. Of the remaining equations, only the LM-LBM produced significant bias (+10 % in median) according to line of identity regression analysis. The LM equation yielded marginally higher accuracy (76 %) than the LM-LBM equation (74 %) and the CB (73 %), but lower than the cystatin C-based equation (82 %). However, the estimated accuracy figures for these four equations were generally imprecise and none of the differences compared with the LM equation was statistically significant. Conclusion . In contrast to most creatinine-based GFR prediction equations, the LM equation performs adequately for both children and adults. This may be due to the unique model-building principles used when the LM equation was established. Further validation in a larger paediatric population is necessary.}},
author = {{Nyman, Ulf and Björk, Jonas and Lindström, Veronica and Grubb, Anders}},
issn = {{1502-7686}},
keywords = {{kidney; kidney disease; Drug therapy; glomerular filtration rate; function tests; renal insufficiency}},
language = {{eng}},
number = {{7}},
pages = {{568--576}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children}},
url = {{http://dx.doi.org/10.1080/00365510801915163}},
doi = {{10.1080/00365510801915163}},
volume = {{68}},
year = {{2008}},
}