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Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis

Eriksson, Maria A. ; Rask, Eva ; Johnson, Owe ; Carlstrom, Kjell ; Ahrén, Bo LU ; Eliasson, Mats ; Boman, Kurt and Soderberg, Stefan (2008) In Blood Coagulation and Fibrinolysis 19(7). p.625-632
Abstract
The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status - or dysfibrinolysis - in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recruited from the Monitoring of trends and determinants in Cardiovascular disease (MONICA) population sample, representing the highest and lowest quartiles of fasting insulin levels. Lipids, fibrinolytic status [plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (tPA) mass and activity, and tPA-PAI complex], leptin,... (More)
The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status - or dysfibrinolysis - in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recruited from the Monitoring of trends and determinants in Cardiovascular disease (MONICA) population sample, representing the highest and lowest quartiles of fasting insulin levels. Lipids, fibrinolytic status [plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (tPA) mass and activity, and tPA-PAI complex], leptin, testosterone and sex-hormone-binding globulin were measured. Insulin sensitivity was estimated using the euglycaemic clamp technique. Body composition was determined by bioimpedance. Determinants for circulating levels of fibrinolytic factors were explored in a multivariate linear regression analysis. Levels of fibrinolytic variables and estimated insulin sensitivity did not differ between men and women. Leptin was independently associated with reduced fibrinolytic status high PAI-1 activity, low tPA activity, high tPA mass, and high tPA-PAI complex) in men (P<0.001-0.002). In women, fat mass and/or insulin sensitivity were related to these factors (P<0.001-0.03), and leptin only to reduced tPA activity (P = 0.002). Hyperleptinemia, dysfibrinolysis, insulin sensitivity and androgenicity associate differentially in men and women. Blood Coagul Fibrinolysis 19:625-632 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulin resistance, hyperleptinemia, androgens, dysfibrinolysis, sex
in
Blood Coagulation and Fibrinolysis
volume
19
issue
7
pages
625 - 632
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000260159300003
  • scopus:55049128991
  • pmid:18832901
ISSN
1473-5733
DOI
10.1097/MBC.0b013e3283099046
language
English
LU publication?
yes
id
e68ef781-dff4-400a-8808-1d94764d3385 (old id 1284977)
date added to LUP
2016-04-01 11:55:13
date last changed
2024-10-08 14:53:55
@article{e68ef781-dff4-400a-8808-1d94764d3385,
  abstract     = {{The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status - or dysfibrinolysis - in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recruited from the Monitoring of trends and determinants in Cardiovascular disease (MONICA) population sample, representing the highest and lowest quartiles of fasting insulin levels. Lipids, fibrinolytic status [plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (tPA) mass and activity, and tPA-PAI complex], leptin, testosterone and sex-hormone-binding globulin were measured. Insulin sensitivity was estimated using the euglycaemic clamp technique. Body composition was determined by bioimpedance. Determinants for circulating levels of fibrinolytic factors were explored in a multivariate linear regression analysis. Levels of fibrinolytic variables and estimated insulin sensitivity did not differ between men and women. Leptin was independently associated with reduced fibrinolytic status high PAI-1 activity, low tPA activity, high tPA mass, and high tPA-PAI complex) in men (P&lt;0.001-0.002). In women, fat mass and/or insulin sensitivity were related to these factors (P&lt;0.001-0.03), and leptin only to reduced tPA activity (P = 0.002). Hyperleptinemia, dysfibrinolysis, insulin sensitivity and androgenicity associate differentially in men and women. Blood Coagul Fibrinolysis 19:625-632 (C) 2008 Wolters Kluwer Health | Lippincott Williams &amp; Wilkins.}},
  author       = {{Eriksson, Maria A. and Rask, Eva and Johnson, Owe and Carlstrom, Kjell and Ahrén, Bo and Eliasson, Mats and Boman, Kurt and Soderberg, Stefan}},
  issn         = {{1473-5733}},
  keywords     = {{insulin resistance; hyperleptinemia; androgens; dysfibrinolysis; sex}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{625--632}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Blood Coagulation and Fibrinolysis}},
  title        = {{Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis}},
  url          = {{http://dx.doi.org/10.1097/MBC.0b013e3283099046}},
  doi          = {{10.1097/MBC.0b013e3283099046}},
  volume       = {{19}},
  year         = {{2008}},
}