Advanced

Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art - review article

Harrison, A. P. and Pierzynowski, Stefan LU (2008) 24th Congress of the Polish-Physiological-Society In JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 59. p.91-106
Abstract
The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of... (More)
The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of paramount importance include impaired bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
2-oxoglutarate, osteoporoses, melatonin, cholesterol, cancer, collagen, muscle, artery elasticity, absorption, mineral, alpha keto glutarate (AKG)
in
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
volume
59
pages
91 - 106
publisher
Polish Physiological Society
conference name
24th Congress of the Polish-Physiological-Society
external identifiers
  • wos:000259923400005
  • scopus:51349147548
ISSN
0867-5910
language
English
LU publication?
yes
id
91a711d0-fa97-4621-a4fe-6868b90c96be (old id 1285706)
date added to LUP
2009-02-10 14:14:50
date last changed
2017-06-25 04:01:20
@inproceedings{91a711d0-fa97-4621-a4fe-6868b90c96be,
  abstract     = {The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of paramount importance include impaired bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.},
  author       = {Harrison, A. P. and Pierzynowski, Stefan},
  booktitle    = {JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY},
  issn         = {0867-5910},
  keyword      = {2-oxoglutarate,osteoporoses,melatonin,cholesterol,cancer,collagen,muscle,artery elasticity,absorption,mineral,alpha keto glutarate (AKG)},
  language     = {eng},
  pages        = {91--106},
  publisher    = {Polish Physiological Society},
  title        = {Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art - review article},
  volume       = {59},
  year         = {2008},
}